Table 3 MIC range and MIC90 of triazoles of Aspergillus spp. according to the clinical spectrum
Isolates | Aspergillus flavus | Aspergillus fumigatus | Aspergillus. niger | Aspergillus terreus | |
|---|---|---|---|---|---|
Total isolates screened [n (%)] | 114 | 64 (56.1) | 38 (33.3) | 9 (7.9) | 3 (2.6) |
Extrapulmonary IA proven [n (%)] | 8 (7.0) | 7 (6.1) | 0 | 0 | 1 (0.9) |
MIC tested [n (%)] | 7 (6.1) | 6 (5.3) | – | – | 1 (0.9) |
MIC Itraconazole range (mg/L) | 0.25–0.5 | 0.25–0.5 | – | – | 0.25 |
MIC Voriconazole range (mg/L) | 0.5–1 | 0.5–1 | – | – | 1 |
MIC Posaconazole range (mg/L) | 0.06–0.5 | 0.06–0.5 | – | – | 0.5 |
Invasive Pulmonary Aspergillosis (Proven, Putative/Probable) | 17 (14.9) | 12 (10.5) | 4 (3.5) | 1 (0.9) | 0 |
MIC tested [n (%)] | 9 (7.9) | 4 (3.5) | 4 (3.5) | 1 (0.9) | 0 |
MIC Itraconazole range (mg/L) | 0.06–0.5 | 0.06–0.25 | 0.25–0.5 | 0.5 | 0 |
MIC Voriconazole range (mg/L) | 0.5–1 | 0.5–1 | 0.5–1 | 0.5 | 0 |
MIC Posaconazole range (mg/L) | 0.5 | 0.5 | 0.5 | 0.5 | 0 |
Non-Invasive Pulmonary Aspergillosis (CPA, ABPA, SAFS) | 66 (57.9) | 37 (32.5) | 21 (18.4) | 6 (5.3) | 2 (1.8) |
MIC tested [n (%)] | 22 (19.3) | 5 (4.4) | 10 (8.8) | 5 (4.4) | 2 (1.8) |
MIC Itraconazole range (mg/L) | 0.25–1 | 0.25–1 | 0.25–1 | 0.25–1 | 0.25 |
MIC Voriconazole range (mg/L) | 0.125–1 | 0.125–1 | 0.25–1 | 0.25–0.5 | 0.5 |
MIC Posaconazole range (mg/L) | 0.25–1 | 0.5–1 | 0.25–1 | 0.5 | 0.5 |
Saprophytic tracheobronchial Aspergillosis [n (%)] | 23 (20.2) | 8 (7.0) | 13 (11.4) | 2 (1.8) | 0 |
MIC tested [n (%)] | 3 (2.6) | – | 1 (0.9) | 2 (1.8) | – |
MIC Itraconazole range (mg/L) | 0.25–1 | – | 0.25 | 0.5–1 | – |
MIC Voriconazole range (mg/L) | 0.25–1 | – | 1 | 0.25–0.5 | – |
MIC Posaconazole range (mg/L) | 0.25–0.5 | – | 0.5 | 0.25–0.5 | – |