First report of plasmid-mediated colistin resistance mcr-8.1 gene from a clinical Klebsiella pneumoniae isolate from Lebanon

Table 1 Characteristics of all reported mcr-8.1carrying isolates. COL: colistin; MIC: minimal inhibitory concentration; CC: clonal complex

#	Isolate	Source	City, Country	COL MIC (mg/L)	Antibiotic Resistance Genes	ST	CC	Reference
1	K. pneumoniae k9	Urine (Human)	Beirut, Lebanon	10	mcr-8.1, bla_DHA-1, bla_SHV-12, bla_SHV-13, bla_SHV-31, bla_SHV-86, bla_SHV-129, bla_SHV-155, bla_SHV-172, aac(6′)-Ib-cr, aadA1, aadA16, aadA2b, aph(3′)-Ia, aac(6′)-Ib-cr, oqxA, oqxB, qnrB2, qnrB4, qnrB52, sul1, sul3, fosA, mph(A), mph(E), msr(E), tetD, dfrA27, cmlA1, floR, arr-3	15	23	This study
2	K. pneumoniae KP91	Swine feces (Animal)	Shandong, China	16	mcr-8.1, bla_CTX-M-14, bla_SHV-1, strA, strB, armA, aph(4)-Ia, mph(E), msr(E), oqxA,qnrB4, sul1, sul2, sul3, tet(A), tet(B), tet(34), dfrA12	42		[4]
3	K. pneumoniae KP95	Oral cavity pus (Human)	Sétif, Algeria	8	mcr-8.1, bla_OXA-48, bla_CTX-M-15, bla_SHV-94,bla_OXA-1, bla_TEM-1B, aph(3′)-la, aac(6′)-lb-cr, aph(3″)-lb, aph(6)-ld, oqxB,oqxA, fosA, catB3, sul2, dfrA14	336		[6]
4	R. ornithinolytica QDRO2	Chicken cloaca (Animal)	Shandong, China	8	mcr-8.1, bla_TEM-1B, bla_OXA-1, bla_SHV-73, aac(3)-IVa, aph(4)-Ia, aadA2, fosA, mph(A), mph(E), cat, floR, cml, qnrS4, oqxAB, nrB52, sul1, sul2, sul3, tet(A), tet(34), tet(O), tet(B)			[26]

ISSN: 2047-2994