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Table 4 Distributions of fosfomycin-resistant related genes corresponding MIC values among MRSA isolates

From: Prevalence of fosfomycin resistance and gene mutations in clinical isolates of methicillin-resistant Staphylococcus aureus

uhpT mutationa glpT mutationb murA mutationc fosB gene t002 t037 Other spa types Total
n FOS range n FOS range n FOS range n FOS range
Wild type Wild type Wild type Positive 0 0 1 128 1 128
Wild type Type I Wild type Positive 1 >  2048 0 0 1 >  2048
Wild type Type I Wild type Negative 3 >  2048 0 1 >  2048 4 >  2048
Wild type Type II Type I Negative 0 2 >  2048 0 2 >  2048
Wild type Type VI Wild type Negative 0 1 64 0 1 64
Type I Wild type Type I Negative 0 1 128 0 1 128
Type I Type I Wild type Positive 9 >  2048 0 0 9 >  2048
Type I Type I Wild type Negative 31 1024 - >  2048 0 7 >  2048 38 1024 - >  2048
Type I Type I Type III Positive 1 >  2048 0 0 1 >  2048
Type I Type I Type IV Negative 2 >  2048 0 0 2 >  2048
Type I Type I Type V Negative 1 >  2048 0 0 1 >  2048
Type I Type I Type VII Negative 1 >  2048 0 0 1 >  2048
Type I Type III Wild type Negative 1 128 0 0 1 128
Type I Type IV Wild type Negative 1 >  2048 0 0 1 >  2048
Type II Type I Wild type Negative 1 >  2048 0 0 1 >  2048
Type II Type I Type VI Negative 0 0 1 >  2048 1 >  2048
Type III Type I Type II Negative 0 0 1 256 1 256
Type IV Type V Type I Negative 0 1 2048 0 1 2048
  1. a Type I: A279V; Type II: A297V/E225D; Type III: F267L/L281X; Type IV: G161R; Wild type: no mutations detected
  2. b Type I: A434V; Type II: W147X; Type III: F197I; Type IV: A434V/G399S; Type V: C57X; Type VI: T313K; Wild type: no mutations detected
  3. c Type I: G257D; Type II: D278E; Type III: deletion at position 717; Type IV: G322S; Type V: L162I; Type VI: E271Q; Type VII: G240R; Wild type: no mutations detected