TY - JOUR AU - Aslam, Bilal AU - Rasool, Maria AU - Idris, Adi AU - Muzammil, Saima AU - Alvi, Roman Farooq AU - Khurshid, Mohsin AU - Rasool, Muhammad Hidayat AU - Zhang, Derong AU - Ma, Zhongren AU - Baloch, Zulqarnain PY - 2020 DA - 2020/08/10 TI - CRISPR-Cas system: a potential alternative tool to cope antibiotic resistance JO - Antimicrobial Resistance & Infection Control SP - 131 VL - 9 IS - 1 AB - Antibiotic exposure leads to massive selective pressures that initiate the emergence and spread of antibiotic resistance in commensal and pathogenic bacteria. The slow process of developing new antibiotics makes this approach counterintuitive for combatting the rapid emergence of new antibiotic resistant pathogens. Therefore, alternative approaches such as, the development of nucleic acid-based anti-bacterial treatments, anti-bacterial peptides, bacteriocins, anti-virulence compounds and bacteriophage therapies should be exploited to cope infections caused by resistant superbugs. In this editorial, we discuss how the newly popular CRISPR-Cas system has been applied to combat antibiotic resistance. SN - 2047-2994 UR - https://doi.org/10.1186/s13756-020-00795-6 DO - 10.1186/s13756-020-00795-6 ID - Aslam2020 ER -