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Table 4 Factors associated with 30-days mortality by univariate analysis in inpatients with candidaemia

From: A seven-year surveillance study of the epidemiology, antifungal susceptibility, risk factors and mortality of candidaemia among paediatric and adult inpatients in a tertiary teaching hospital in China

Variable

Adult patients (> 16 years)

30-days outcome

P-value

Child patients (0–16 years)

30-days outcome

P-value

All patients

30-days outcome

P-value

Survived

(n = 133)

Died

(n = 33)

Survived (n = 32)

Died

(n = 3)

Survived (n = 165)

Died

(n = 36)

Median age(range)

60 years

(18, 92 years)

67 years

(29, 86 years)

0.001

1 days

(1 day, 5 year)

1 days (1 day,1 day)

0.585

52 years

(1 day, 92 years)

65 years

(1 day, 86 years)

0.001

Gender (male:female)

72:61

20:13

0.503

19:13

3:0

0.164

91:74

23:13

0.557

Length of hospital stay(days)

35.3 ± 42.8

11.7 ± 9.2

0.002

43.8 ± 20.2

16.7 ± 8.5

0.029

36.9 ± 39.5

12.1 ± 9.1

< 0.001

Underlying comorbidities (n, %)

         

Gastrointestinal perforation

15(11.3)

7(21.2)

0.132

2(6.3)

0(0)

0.656

17 (10.3)

7 (19.4)

0.125

Respiratory dysfunction

28(21.1)

27(81.8)

< 0.001

1(3.1)

2(66.7)

< 0.001

29(17.6)

29 (80.6)

< 0.001

Pulmonary infection

54(40.6)

22(66.7)

0.007

22(68.8)

2(66.7)

0.941

76(46.1)

24(66.7)

0.025

Cardiovascular disease

56(42.1)

27(81.8)

< 0.001

3(9.4)

0(0)

0.579

59 (35.8)

27 (75.0)

< 0.001

Neurological diseases

41(30.8)

13(39.4)

0.347

22(68.8)

2(66.7)

0.941

63 (38.2)

15 (41.7)

0.697

Gastrointestinal pathology

42(31.6)

14(42.4)

0.238

2(6.3)

0(0)

0.656

44(26.7)

14 (38.9)

0.143

Chronic/acute liver disease

30(22.6)

10(30.3)

0.352

9(28.1)

0(0)

0.287

39 (23.6)

10 (27.8)

0.600

Chronic/acute renal failure

60(45.1)

22(66.7)

0.027

6(18.8)

3(100.0)

0.002

66 (40.0)

22 (61.1)

0.001

Haematological malignancy

4(3.0)

3(9.1)

0.120

2(6.3)

2()

0.656

6(36.4)

5(13.9)

0.217

Solid tumour

12(9.0)

3(9.1)

0.990

0(0)

0(0)

–

12(7.3)

3 (8.3)

0.826

Severe autoimmune diseases

12(9.0)

3(9.1)

0.990

0(0)

0(0)

–

12(7.3)

3 (8.3)

0.826

Congenital malformations/syndromes

0

0

–

5(15.6)

1(33.3)

0.365

5 (3.0)

1 (2.8)

0.799

Hematologic (nonmalignant)

12(9.0)

7(21.2)

0.049

9(28.1)

1(33.3)

0.849

21 (12.7)

8 (22.2)

0.142

Diabetes mellitus

45(33.8)

15(45.5)

0.214

0(0)

0(0)

–

45(27.3)

15 (41.7)

0.087

HIV/AIDS

9(6.8)

1(3.0)

0.419

0(0)

0(0)

–

9(5.5)

1 (2.8)

0.503

Severe trauma

12(9.0)

3(9.1)

0.990

2(6.3)

0(0)

0.565

14(8.5)

3 (8.3)

0.976

Risk factors (n, %)

         

premature neonates≤36 weeks)a

–

–

–

28(87.5)

2(66.7)

0.515

28(93.3)

2(100.0)

0.706

Very low birth weight neonates(<1500 g)a

–

–

–

19(59.4)

2(66.7)

0.886

19(63.3)

2(100.0)

0.290

Presence of CVC

57(42.9)

13(39.4)

0.718

6(18.8)

1(33.3)

0.546

63(38.2)

14 (38.9)

0.937

Other invasive catheters

51(38.3)

4(12.1)

0.004

5(15.6)

0(0)

0.460

56(33.9)

4(11.1)

0.007

Mechanical ventilation

45(33.8)

21(63.6)

0.002

19(59.4)

2(66.7)

0.805

64(38.8)

23 (63.9)

0.006

Receipt of corticosteroids

27(20.3)

6(18.2)

0.785

9(18.1)

0(0)

0.287

36 (21.8)

6(16.7)

0.491

Total parenteral nutrition

57(42.9)

20(60.6)

0.067

17(53.1)

1(33.3)

0.512

74(44.8)

21(58.3)

0.142

Malnutrition

36(27.1)

10(30.3)

0.710

8(25.0)

1(33.3)

0.752

44(26.7)

11(30.6)

0.635

Chemotherapy

16(12.0)

2(6.1)

0.324

2(6.3)

0(0)

0.656

18 (10.9)

2 (5.6)

0.331

Abdominal surgery

24(18.0)

7(21.2)

0.676

0(0)

0(0)

–

24(14.5)

7 (19.4)

0.461

Hemodialysis

22(16.5)

8(24.2)

0.303

0(0)

0(0)

–

22(13.3)

8(22.2)

0.175

ICU/PICU/NICU

33(24.8)

13(39.4)

0.094

32(100.0)

3(100.0)

–

65(39.4)

16 (44.4)

0.576

Neutropeniag

13(9.8)

3(9.1)

0.905

0(0)

0(0)

–

13(7.9)

3 (8.3)

0.927

Concomitant bacterial infections

59(44.4)

21(63.6)

0.047

27(84.4)

3(100.0)

0.460

86 (52.1)

24 (66.7)

0.112

Septic shock

8(6.0)

28(84.8)

< 0.001

1(3.1)

2(66.7)

< 0.001

9 (5.5)

30 (83.3)

< 0.001

Broad-spectrum antibiotics

115(86.5)

29(87.9)

0.830

32(100.0)

3(100.0)

–

147(89.1)

32(88.9)

0.972

Treatment with antifungal agents

71(53.4)

16(48.5)

0.614

24(75.0)

3(100.0)

0.324

95(57.6)

19(52.8)

0.599

Species, n (%)

         

C. albicans

47(35.3)

18(54.5)

0.043

16(50.0)

0(0)

0.096

63 (38.2)

18 (50.0)

0.190

C. glabrata

46(34.6)

9(27.3)

0.424

15(46.9)

3(100.0)

0.078

61 (37.0)

12 (33.3)

0.681

  1. ICU intensive care unit; PICU pediatric intensive care unit, NICU neonatal intensive care unit, CVC central venous catheter
  2. aOnly neonatal cases were analyzed
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Antimicrobial Resistance & Infection Control

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