Skip to main content

Table 4 Factors associated with 30-days mortality by univariate analysis in inpatients with candidaemia

From: A seven-year surveillance study of the epidemiology, antifungal susceptibility, risk factors and mortality of candidaemia among paediatric and adult inpatients in a tertiary teaching hospital in China

Variable Adult patients (> 16 years)
30-days outcome
P-value Child patients (0–16 years)
30-days outcome
P-value All patients
30-days outcome
P-value
Survived
(n = 133)
Died
(n = 33)
Survived (n = 32) Died
(n = 3)
Survived (n = 165) Died
(n = 36)
Median age(range) 60 years
(18, 92 years)
67 years
(29, 86 years)
0.001 1 days
(1 day, 5 year)
1 days (1 day,1 day) 0.585 52 years
(1 day, 92 years)
65 years
(1 day, 86 years)
0.001
Gender (male:female) 72:61 20:13 0.503 19:13 3:0 0.164 91:74 23:13 0.557
Length of hospital stay(days) 35.3 ± 42.8 11.7 ± 9.2 0.002 43.8 ± 20.2 16.7 ± 8.5 0.029 36.9 ± 39.5 12.1 ± 9.1 < 0.001
Underlying comorbidities (n, %)          
Gastrointestinal perforation 15(11.3) 7(21.2) 0.132 2(6.3) 0(0) 0.656 17 (10.3) 7 (19.4) 0.125
Respiratory dysfunction 28(21.1) 27(81.8) < 0.001 1(3.1) 2(66.7) < 0.001 29(17.6) 29 (80.6) < 0.001
Pulmonary infection 54(40.6) 22(66.7) 0.007 22(68.8) 2(66.7) 0.941 76(46.1) 24(66.7) 0.025
Cardiovascular disease 56(42.1) 27(81.8) < 0.001 3(9.4) 0(0) 0.579 59 (35.8) 27 (75.0) < 0.001
Neurological diseases 41(30.8) 13(39.4) 0.347 22(68.8) 2(66.7) 0.941 63 (38.2) 15 (41.7) 0.697
Gastrointestinal pathology 42(31.6) 14(42.4) 0.238 2(6.3) 0(0) 0.656 44(26.7) 14 (38.9) 0.143
Chronic/acute liver disease 30(22.6) 10(30.3) 0.352 9(28.1) 0(0) 0.287 39 (23.6) 10 (27.8) 0.600
Chronic/acute renal failure 60(45.1) 22(66.7) 0.027 6(18.8) 3(100.0) 0.002 66 (40.0) 22 (61.1) 0.001
Haematological malignancy 4(3.0) 3(9.1) 0.120 2(6.3) 2() 0.656 6(36.4) 5(13.9) 0.217
Solid tumour 12(9.0) 3(9.1) 0.990 0(0) 0(0) 12(7.3) 3 (8.3) 0.826
Severe autoimmune diseases 12(9.0) 3(9.1) 0.990 0(0) 0(0) 12(7.3) 3 (8.3) 0.826
Congenital malformations/syndromes 0 0 5(15.6) 1(33.3) 0.365 5 (3.0) 1 (2.8) 0.799
Hematologic (nonmalignant) 12(9.0) 7(21.2) 0.049 9(28.1) 1(33.3) 0.849 21 (12.7) 8 (22.2) 0.142
Diabetes mellitus 45(33.8) 15(45.5) 0.214 0(0) 0(0) 45(27.3) 15 (41.7) 0.087
HIV/AIDS 9(6.8) 1(3.0) 0.419 0(0) 0(0) 9(5.5) 1 (2.8) 0.503
Severe trauma 12(9.0) 3(9.1) 0.990 2(6.3) 0(0) 0.565 14(8.5) 3 (8.3) 0.976
Risk factors (n, %)          
premature neonates≤36 weeks)a 28(87.5) 2(66.7) 0.515 28(93.3) 2(100.0) 0.706
Very low birth weight neonates(<1500 g)a 19(59.4) 2(66.7) 0.886 19(63.3) 2(100.0) 0.290
Presence of CVC 57(42.9) 13(39.4) 0.718 6(18.8) 1(33.3) 0.546 63(38.2) 14 (38.9) 0.937
Other invasive catheters 51(38.3) 4(12.1) 0.004 5(15.6) 0(0) 0.460 56(33.9) 4(11.1) 0.007
Mechanical ventilation 45(33.8) 21(63.6) 0.002 19(59.4) 2(66.7) 0.805 64(38.8) 23 (63.9) 0.006
Receipt of corticosteroids 27(20.3) 6(18.2) 0.785 9(18.1) 0(0) 0.287 36 (21.8) 6(16.7) 0.491
Total parenteral nutrition 57(42.9) 20(60.6) 0.067 17(53.1) 1(33.3) 0.512 74(44.8) 21(58.3) 0.142
Malnutrition 36(27.1) 10(30.3) 0.710 8(25.0) 1(33.3) 0.752 44(26.7) 11(30.6) 0.635
Chemotherapy 16(12.0) 2(6.1) 0.324 2(6.3) 0(0) 0.656 18 (10.9) 2 (5.6) 0.331
Abdominal surgery 24(18.0) 7(21.2) 0.676 0(0) 0(0) 24(14.5) 7 (19.4) 0.461
Hemodialysis 22(16.5) 8(24.2) 0.303 0(0) 0(0) 22(13.3) 8(22.2) 0.175
ICU/PICU/NICU 33(24.8) 13(39.4) 0.094 32(100.0) 3(100.0) 65(39.4) 16 (44.4) 0.576
Neutropeniag 13(9.8) 3(9.1) 0.905 0(0) 0(0) 13(7.9) 3 (8.3) 0.927
Concomitant bacterial infections 59(44.4) 21(63.6) 0.047 27(84.4) 3(100.0) 0.460 86 (52.1) 24 (66.7) 0.112
Septic shock 8(6.0) 28(84.8) < 0.001 1(3.1) 2(66.7) < 0.001 9 (5.5) 30 (83.3) < 0.001
Broad-spectrum antibiotics 115(86.5) 29(87.9) 0.830 32(100.0) 3(100.0) 147(89.1) 32(88.9) 0.972
Treatment with antifungal agents 71(53.4) 16(48.5) 0.614 24(75.0) 3(100.0) 0.324 95(57.6) 19(52.8) 0.599
Species, n (%)          
C. albicans 47(35.3) 18(54.5) 0.043 16(50.0) 0(0) 0.096 63 (38.2) 18 (50.0) 0.190
C. glabrata 46(34.6) 9(27.3) 0.424 15(46.9) 3(100.0) 0.078 61 (37.0) 12 (33.3) 0.681
  1. ICU intensive care unit; PICU pediatric intensive care unit, NICU neonatal intensive care unit, CVC central venous catheter
  2. aOnly neonatal cases were analyzed