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Table 2 Sepsis and mortality before and after guideline update

From: Sepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms

Year of discharge

2011–2013

n = 3.920

(%, 95 CI)

2014–2018

n = 8.903

(%, 95 CI)

p#

Sepsis with positive blood culture

16.5 (15.3–17.6)

14.4 (13.7–15.1)

0.003

Clinical sepsisa

42.8 (41.1–44.6)

31.4 (30.4–32.4)

< 0.001

Early-onset sepsisa with positive blood culture

1.7 (1.3–2.2)

1.4 (1.2–1.8)

0.3

Late-onset sepsisa with positive blood culture

17.0 (15.7–18.4)

14.9 (14.0–15.8) %

0.008

Gram positive sepsis

13.2 (12.2–14.3)

11.2 (10.6–11.9) %

0.001

Gram negative sepsis

3.8 (3.2–4.4)

3.4 (3.0–3.8) %

0.26

KRINKO I/MDRO sepsis

0.5 (0.3–0.7)

0.6 (0.5–0.8) %

0.36

KRINKO II sepsis

2.0 (1.6–2.5)

2.2 (1.9–2.6) %

0.49

KRINKO III sepsis

1.1 (0.8–1.5)

1.1 (0.9–1.3) %

0.98

Candida sepsis

0.5 (0.3–0.7)

0.4 (0.3–0.6) %

0.52

Sepsis related mortality

2.3 (1.8–2.8)

2.1 (1.8–2.4) %

0.54

Total mortality

(%, 95 CI)

13.8 (12.8–14.9)

12.5 (11.8–13.2) %

0.036

  1. KRINKO I – all MDRO, KRINKO II – Acinetobacter spp., Klebsiella spp., S. aureus without MDRO; KRINKO III – pathogens with high epidemic potential but no MDRO i.e. Serratia marcescens, Pseudomonas aeruginosa, Klebsiella and Enterobacter spp. #Fisher’s exact test (two-sided)
  2. aThe data is based on the population of infants enrolled in the GNN (n = 2.948/6.630)