Skip to main content

Table 2 Sepsis and mortality before and after guideline update

From: Sepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms

Year of discharge 2011–2013
n = 3.920
(%, 95 CI)
2014–2018
n = 8.903
(%, 95 CI)
p#
Sepsis with positive blood culture 16.5 (15.3–17.6) 14.4 (13.7–15.1) 0.003
Clinical sepsisa 42.8 (41.1–44.6) 31.4 (30.4–32.4) < 0.001
Early-onset sepsisa with positive blood culture 1.7 (1.3–2.2) 1.4 (1.2–1.8) 0.3
Late-onset sepsisa with positive blood culture 17.0 (15.7–18.4) 14.9 (14.0–15.8) % 0.008
Gram positive sepsis 13.2 (12.2–14.3) 11.2 (10.6–11.9) % 0.001
Gram negative sepsis 3.8 (3.2–4.4) 3.4 (3.0–3.8) % 0.26
KRINKO I/MDRO sepsis 0.5 (0.3–0.7) 0.6 (0.5–0.8) % 0.36
KRINKO II sepsis 2.0 (1.6–2.5) 2.2 (1.9–2.6) % 0.49
KRINKO III sepsis 1.1 (0.8–1.5) 1.1 (0.9–1.3) % 0.98
Candida sepsis 0.5 (0.3–0.7) 0.4 (0.3–0.6) % 0.52
Sepsis related mortality 2.3 (1.8–2.8) 2.1 (1.8–2.4) % 0.54
Total mortality
(%, 95 CI)
13.8 (12.8–14.9) 12.5 (11.8–13.2) % 0.036
  1. KRINKO I – all MDRO, KRINKO II – Acinetobacter spp., Klebsiella spp., S. aureus without MDRO; KRINKO III – pathogens with high epidemic potential but no MDRO i.e. Serratia marcescens, Pseudomonas aeruginosa, Klebsiella and Enterobacter spp. #Fisher’s exact test (two-sided)
  2. aThe data is based on the population of infants enrolled in the GNN (n = 2.948/6.630)