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Table 1 The WPR rates for each antimicrobial

From: Antimicrobial resistance in Clostridioides (Clostridium) difficile derived from humans: a systematic review and meta-analysis

Antimicrobials Breakpoint (mg/L) Number of isolates tested Number of resistant isolates n (%) Weighted pooled resistance rate 95% Confidence interval Heterogeneity
Metronidazole >2 5900 190 (3.2) 0.01 0–0.03 91.97
Metronidazole ≥32 13,207 129 (1.0) 0.00 0–0.00 81.4
Vancomycin ≥32 2307 13 (0.6) 0.00 0–0.00 38.6
Vancomycin ≥16 2296 10 (0.4) 0.00 0–0.00 7.62
Vancomycin ≥4 1107 7 (0.6) 0.00 0–0.01 50.1
Vancomycin >2 11,188 416 (3.7) 0.01 0–0.02 89.79
Moxifloxacin ≥8 11,484 3912 (34.1) 0.32 0.25–0.4 93.89
Meropenem ≥16 2756 20 (0.7) 0.00 0–0.01 71.49
Piperacillin/Tazobactam ≥128/4 3041 8 (0.3) 0.00 0–0.00 0
Clindamycin ≥8 19,645 6685 (34.0) 0.59 0.53–0.65 97.50
Ciprofloxacin ≥8 4339 3356 (77.0) 0.95 0.85–1.0 99.12
Tetracycline ≥16 4861 886 (18.2) 0.20 0.14–0.27 97.04
Amoxicillin/Clavulanate ≥16/8 2803 4 (0.1) 0.00 0–0.00 45.4
Ceftriaxone ≥64 3476 1289 (37.1) 0.47 0.29–0.65 99.05
Rifampin >0.004 1861 787 (42.3) 0.37 0.18–0.58 97.69
Moxifloxacin >4 2809 929 (33.1) 0.49 0.30–0.67 98.68
Tigecycline >0.25 2375 39 (1.6) 0.01 0–0.03 83.53
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