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Table 3 Probabilities associated with colonisation necessary in a “One-Health” cost model

From: A one health framework to estimate the cost of antimicrobial resistance

Data element Probability
Morbidity (Human health) Probability of developing infection in colonised individuals,
Probability of contact precautions/isolation when colonised
Probability of lower quality care when colonised or of missed care opportunity (e.g., surgical prophylaxis not administered in patients known to be colonised)
Probability of undergoing diagnostic tests
Probability of non-standard surgical prophylaxis
Probability of being treated even in absence of infection, due to known colonisation status (increase in selection pressure related to environmental contamination)
Lower quality of life
Morbidity (Animal health) For companion animals, probability of being screened for colonisation with AMR pathogens (e.g. MRSA) in referral veterinary practices.
Probability of developing infection in colonised animals
Probability of surveillance of faecal samples for MDR organisms under public health programmes
Mortality (Animal health) Probability of the animal being slaughtered due to colonisation with resistant pathogen.
Screening (Humans / animals) Probability of starting a screening programme when there is a colonised patient (Number of colonised patients to trigger a screening programme) (humans / animals)
Bi-directional Transmission of colonisation between One Health Areas Probability of each of 6 possible broad paths between One Health areas, and within-area probability of transmission (e.g. between LTCF and hospitals and vice versa)