Organism/antibiotic | No. of isolates | MIC50 | MIC90 | MIC range | CLSI | EUCAST | ||||
---|---|---|---|---|---|---|---|---|---|---|
S% | I% | R% | S% | I% | R% | |||||
Staphylococcus aureus | ||||||||||
Ceftaroline | 50525 | 0.5 | 1 | 0.015–64 | 93.4 | 6.2 | 0.4 | 93.4 | 6.2 | 0.4 |
Ceftazidime–avibactam | 50525 | 32 | 64 | 0.015–64 | NA | NA | NA | NA | NA | NA |
Ceftazidime | 50525 | 32 | 64 | 0.015–64 | NA | NA | NA | NA | NA | NA |
Pip-taz | 50525 | 8 | 32 | 0.12–32 | NA | NA | NA | NA | NA | NA |
Levofloxacin | 50525 | 0.5 | 8 | 0.015–8 | 56.9 | 0.4 | 42.7 | 56.9 | 0 | 43.1 |
Moxifloxacin | 50525 | 0.12 | 4 | 0.008–8 | 57.1 | 2.7 | 40.1 | 56.8 | 0 | 43.2 |
Tigecycline | 50525 | 0.12 | 0.25 | 0.015–4 | 98.9 | 1.1 | 0 | 98.9 | 0 | 1.1 |
Minocycline | 50525 | 0.12 | 1 | 0.12–16 | 93.2 | 3.4 | 3.4 | 89.4 | 1.4 | 9.2 |
Gentamicin | 31019 | 0.5 | 64 | 0.06–64 | 85 | 0.7 | 14.3 | 56.1 | 0 | 43.9 |
Daptomycin | 50525 | 0.5 | 1 | 0.06–4 | 99.8 | 0.2 | 0 | 99.8 | 0 | 0.2 |
Trimethoprim sulfa | 31019 | 0.25 | 1 | 0.25–8 | 96.8 | 0 | 3.3 | 96.8 | 0.7 | 2.6 |
Teicoplanin | 50525 | 0.5 | 1 | 0.12–32 | 100 | 0 | 0 | 98.1 | 0 | 1.9 |
Vancomycin | 50525 | 1 | 2 | 0.25–4 | 100 | 0 | 0 | 100 | 0 | 0 |
Clindamycin | 50525 | 0.12 | 4 | 0.03–8 | 74.8 | 0.3 | 24.9 | 74.2 | 0.6 | 25.2 |
Erythromycin | 50525 | 1 | 16 | 0.12–16 | 48 | 3.4 | 48.6 | 50.6 | 0.3 | 49.1 |
Linezolid | 50525 | 2 | 2 | 0.5–16 | 100 | 0 | 0 | 100 | 0 | 0 |
Oxacillin | 50525 | 4 | 8 | 0.06–8 | 40.4 | 0 | 59.6 | NA | NA | NA |
Streptococcus pneumoniae | ||||||||||
Ceftaroline | 11005 | 0.008 | 0.12 | 0.004–32 | 99.7 | 0.3 | 0 | 98.7 | 0 | 1.3 |
Ceftazidime–avibactam | 11005 | 0.25 | 16 | 0.015–128 | NA | NA | NA | NA | NA | NA |
Ceftazidime | 11005 | 0.25 | 16 | 0.015–128 | NA | NA | NA | NA | NA | NA |
Doripenem | 11005 | 0.015 | 1 | 0.015–8 | 98 | 2 | 0 | 98 | 0 | 2 |
Meropenem | 11005 | 0.015 | 1 | 0.008–2 | 78 | 9.2 | 12.8 | 100 | 0 | 0 |
Levofloxacin | 11005 | 1 | 1 | 0.12–16 | 98.5 | 0.2 | 1.3 | 98.5 | 0 | 1.5 |
Moxifloxacin | 11005 | 0.12 | 0.25 | 0.03–8 | 98.5 | 0.5 | 1.1 | 98.4 | 0 | 1.6 |
Tigecycline | 11005 | 0.03 | 0.03 | 0.008–2 | 99.9 | 0.1 | 0 | NA | NA | NA |
Minocycline | 11005 | 0.12 | 4 | 0.015–4 | 71.3 | 5.1 | 23.6 | 69.6 | 1.7 | 28.7 |
Daptomycin | 11005 | 0.25 | 0.5 | 0.03–8 | NA | NA | NA | NA | NA | NA |
Vancomycin | 11005 | 0.25 | 0.5 | 0.008–2 | 100 | 0 | 0 | 100 | 0 | 0 |
Clindamycin | 11005 | 0.06 | 2 | 0.008–2 | 74.8 | 0.4 | 24.8 | 75.2 | 0 | 24.8 |
Erythromycin | 11005 | 0.06 | 2 | 0.008–2 | 64.3 | 0.3 | 35.4 | 64.3 | 0.3 | 35.4 |
Linezolid | 11005 | 1 | 2 | 0.06–4 | 100 | 0 | 0 | 100 | 0 | 0 |
Penicillin | 11005 | 0.03 | 2 | 0.015–16 | 61.8 | 20.7 | 17.5 | 61.8 | 28.9 | 9.3 |
α-hemolytic Streptococcus | ||||||||||
Ceftaroline | 12138 | 0.008 | 0.12 | 0.004–32 | 99.7 | 0.3 | 0 | 98.7 | 0 | 1.3 |
Ceftazidime–avibactam | 12138 | 0.25 | 16 | 0.015–128 | NA | NA | NA | NA | NA | NA |
Ceftazidime | 12138 | 0.25 | 16 | 0.015–128 | NA | NA | NA | NA | NA | NA |
Penicillin | 12138 | 0.03 | 2 | 0.015–16 | NA | NA | NA | NA | NA | NA |
Doripenem | 12138 | 0.015 | 1 | 0.015–8 | NA | NA | NA | 98 | 0 | 2 |
Meropenem | 12138 | 0.015 | 1 | 0.008–2 | NA | NA | NA | 100 | 0 | 0 |
Levofloxacin | 12138 | 1 | 2 | 0.12–16 | 98.3 | 0.3 | 1.4 | 98.5 | 0 | 1.5 |
Moxifloxacin | 12138 | 0.12 | 0.25 | 0.03–8 | 98.5 | 0.5 | 1.1 | 98.4 | 0 | 1.6 |
Minocycline | 12138 | 0.12 | 4 | 0.015–4 | NA | NA | NA | 69.6 | 1.7 | 28.7 |
Tigecycline | 12138 | 0.03 | 0.03 | 0.008–2 | NA | NA | NA | 100 | 0 | 0 |
Clindamycin | 12138 | 0.06 | 2 | 0.008–2 | 75.6 | 0.4 | 24.1 | 75.9 | 0 | 24.1 |
Erythromycin | 12138 | 0.06 | 2 | 0.008–2 | 64.8 | 0.3 | 34.9 | 64.3 | 0.3 | 35.4 |
Vancomycin | 12138 | 0.5 | 0.5 | 0.008–2 | 100 | 0 | 0 | 100 | 0 | 0 |
Linezolid | 12138 | 1 | 2 | 0.06–8 | 100 | 0 | 0 | 100 | 0 | 0 |
Daptomycin | 12138 | 0.25 | 0.5 | 0.03–8 | 99.3 | 0.7 | 0 | 100 | 0 | 0 |
β-hemolytic Streptococcus | ||||||||||
Ceftaroline | 9019 | 0.004 | 0.015 | 0.004–1 | 100 | 0 | 0 | NA | NA | NA |
Ceftazidime–avibactam | 9019 | 0.12 | 0.5 | 0.015–128 | NA | NA | NA | NA | NA | NA |
Ceftazidime | 9019 | 0.12 | 0.5 | 0.015–128 | NA | NA | NA | NA | NA | NA |
Penicillin | 9019 | 0.015 | 0.06 | 0.015–8 | NA | NA | NA | NA | NA | NA |
Doripenem | 9019 | 0.015 | 0.03 | 0.015–8 | NA | NA | NA | 100 | 0 | 0 |
Meropenem | 9019 | 0.015 | 0.06 | 0.008–2 | 99.9 | 0.1 | 0 | 100 | 0 | 0 |
Levofloxacin | 9019 | 0.5 | 1 | 0.12–16 | 98.3 | 0.2 | 1.5 | 98.2 | 0 | 1.9 |
Moxifloxacin | 9019 | 0.12 | 0.25 | 0.03–8 | NA | NA | NA | 98.1 | 0 | 1.9 |
Minocycline | 9019 | 0.12 | 4 | 0.015–4 | 69.9 | 30.1 | 0 | 65.6 | 0.9 | 33.4 |
Tigecycline | 9019 | 0.03 | 0.06 | 0.008–2 | 100 | 0 | 0 | 100 | 0 | 0 |
Clindamycin | 9019 | 0.06 | 0.12 | 0.008–2 | 90.6 | 0.3 | 9 | 91 | 0 | 9 |
Erythromycin | 9019 | 0.06 | 2 | 0.008–2 | 83.4 | 0.7 | 15.8 | 84.4 | 0.6 | 15 |
Vancomycin | 9019 | 0.5 | 0.5 | 0.008–1 | 100 | 0 | 0 | 100 | 0 | 0 |
Linezolid | 9019 | 1 | 2 | 0.06–8 | 100 | 0 | 0 | 100 | 0 | 0 |
Daptomycin | 9019 | 0.12 | 0.5 | 0.03–8 | 100 | 0 | 0 | 100 | 0 | 0 |
CoNS | ||||||||||
Ceftaroline | 8490 | 0.25 | 1 | 0.015–64 | NA | NA | NA | NA | NA | NA |
Ceftazidime–avibactam | 8490 | 16 | 64 | 0.015–64 | NA | NA | NA | NA | NA | NA |
Ceftazidime | 8490 | 16 | 64 | 0.015–64 | NA | NA | NA | NA | NA | NA |
Pip-taz | 8490 | 2 | 32 | 0.12–32 | NA | NA | NA | NA | NA | NA |
Levofloxacin | 8490 | 4 | 8 | 0.015–8 | 46.9 | 1.8 | 51.4 | 46.9 | 0 | 53.1 |
Moxifloxacin | 8490 | 1 | 4 | 0.008–8 | NA | NA | NA | NA | NA | NA |
Minocycline | 8490 | 0.25 | 0.5 | 0.12–16 | 48.9 | 14.6 | 36.5 | 46.5 | 0 | 53.5 |
Tigecycline | 8490 | 0.25 | 0.5 | 0.015–4 | 98.7 | 1.3 | 0 | 98.7 | 0 | 1.3 |
Clindamycin | 8490 | 0.12 | 8 | 0.03–8 | 65.5 | 2.1 | 32.4 | 63.7 | 1.9 | 34.5 |
Erythromycin | 8490 | 8 | 16 | 0.12–16 | 33.1 | 1.1 | 65.8 | 33.4 | 0.3 | 66.3 |
Vancomycin | 8490 | 1 | 2 | 0.25–8 | 99.9 | 0.1 | 0 | 99.9 | 0 | 0.1 |
Teicoplanin | 8490 | 2 | 8 | 0.12–64 | 98 | 1.7 | 0.3 | 85 | 0 | 15 |
Linezolid | 8490 | 1 | 2 | 0.5–16 | 99.4 | 0 | 0.6 | 99.4 | 0 | 0.6 |
Daptomycin | 8490 | 0.5 | 1 | 0.06–4 | 99.6 | 0.4 | 0 | 99.6 | 0 | 0.4 |
Gentamicin | 5336 | 2 | 64 | 0.06–64 | 54.7 | 5.5 | 39.8 | 33.8 | 0 | 66.3 |
Trimethoprim sulfa | 5336 | 1 | 8 | 0.25–8 | 61 | 0 | 39 | 61 | 10 | 28.9 |
Oxacillin | 8490 | 4 | 8 | 0.06–8 | 25.7 | 0 | 74.3 | NA | NA | NA |
Enterococcus faecalis | ||||||||||
Ceftaroline | 3194 | 1 | 16 | 0.015–64 | NA | NA | NA | NA | NA | NA |
Ceftazidime–avibactam | 3194 | 64 | 64 | 1–64 | NA | NA | NA | NA | NA | NA |
Ceftazidime | 3194 | 64 | 64 | 1–64 | NA | NA | NA | NA | NA | NA |
Levofloxacin | 3194 | 1 | 16 | 0.06–16 | 68 | 1.1 | 30.8 | NA | NA | NA |
Tigecycline | 3194 | 0.12 | 0.25 | 0.015–4 | 94.1 | 5.9 | 0 | 94.1 | 3.9 | 2 |
Minocycline | 3194 | 16 | 16 | 0.06–16 | 25.8 | 13.7 | 60.5 | NA | NA | NA |
Daptomycin | 3194 | 2 | 4 | 0.06–8 | 99.8 | 0.2 | 0 | NA | NA | NA |
Teicoplanin | 3194 | 0.5 | 0.5 | 0.12–64 | 98.3 | 0.1 | 1.7 | 97.8 | 0 | 2.2 |
Vancomycin | 3194 | 1 | 2 | 0.12–64 | 94.3 | 3.8 | 1.9 | 94.3 | 0 | 5.7 |
Erythromycin | 3194 | 16 | 16 | 0.06–16 | 14.6 | 27.4 | 58 | NA | NA | NA |
Linezolid | 3194 | 1 | 2 | 0.06–8 | 99.3 | 0.6 | 0.2 | 99.8 | 0 | 0.2 |
Quinupristin dalfopristin | 2014 | 8 | 16 | 0.25–16 | 1 | 7.7 | 91.3 | NA | NA | NA |
Enterococcus faecium | ||||||||||
Ceftaroline | 2546 | 64 | 64 | 0.03–64 | NA | NA | NA | NA | NA | NA |
Ceftazidime–avibactam | 2546 | 64 | 64 | 0.12–64 | NA | NA | NA | NA | NA | NA |
Ceftazidime | 2546 | 64 | 64 | 0.12–64 | NA | NA | NA | NA | NA | NA |
Levofloxacin | 2546 | 16 | 16 | 0.06–16 | 12.2 | 3.9 | 83.9 | NA | NA | NA |
Tigecycline | 2546 | 0.12 | 0.25 | 0.015–8 | 95.5 | 4.5 | 0 | 95.5 | 3 | 1.5 |
Minocycline | 2546 | 2 | 16 | 0.06–16 | 55.4 | 12.4 | 32.2 | NA | NA | NA |
Daptomycin | 2546 | 4 | 4 | 0.06–16 | 98 | 2 | 0 | NA | NA | NA |
Teicoplanin | 2546 | 1 | 64 | 0.12–64 | 76 | 1 | 23 | 75.2 | 0 | 24.8 |
Vancomycin | 2546 | 1 | 64 | 0.12–64 | 69.2 | 5 | 25.8 | 69.2 | 0 | 30.8 |
Erythromycin | 2546 | 16 | 16 | 0.06–16 | 3.6 | 11.2 | 85.2 | NA | NA | NA |
Linezolid | 2546 | 1 | 2 | 0.06–16 | 97.4 | 2.5 | 0.2 | 99.8 | 0 | 0.2 |
Quinupristin dalfopristin | 1577 | 1 | 4 | 0.06–16 | 73.2 | 13.9 | 12.9 | NA | NA | NA |