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Table 6 Mutations in the quinolone resistance determining region (QRDR) and minimal inhibitory concentrations (MIC, μg/mL)

From: Fluoroquinolone resistance of Staphylococcus epidermidis isolated from healthy conjunctiva and analysis of their mutations in quinolone-resistance determining region

Mutation type No. of isolates Mutation MIC (μg/mL)
gyrA gyrB parC parE CFX(≥ 4) LFX(≥ 4) MFX(≥ 2)
1 7 Ser84Phe Ser80Tyr 4 4 1
Ser84Phe Ser80Tyr 4 4 1
Ser84Phe - Ser80Tyr - 8 8 2
Ser84Phe - Ser80Tyr - 4 8 1
Ser84Phe - Ser80Tyr - 2 4 1
Ser84Phe - Ser80Tyr - 4 4 1
Ser84Phe - Ser80Tyr - 4 4 1
2 4 Ser84Phe Ser80Phe 8 8 2
Ser84Phe Ser80Phe 16 8 1
Ser84Phe Ser80Phe 8 8 2
Ser84Phe Ser80Phe 8 8 2
3 3 Ser84Phe Ser80Phe + Asp84Val 16 8 2
Ser84Phe Ser80Phe + Asp84Val 32 8 2
Ser84Phe Ser80Phe + Asp84Val 32 8 2
4 1 Ser84Tyr Ser80Ile 32 8 2
5 1 Ser84Tyr Ser80Ile Lys402Arg + Asn404Ile 16 8 2
6 1 Ser84Phe Ser80Phe + Asp84Val Lys403Thr + Asn404Asp 16 8 2
7 1 Ser84Phe Ser80Phe + Asp84Val Lys402Arg + Lys403Arg 32 8 2
8 1 Ser84Tyr + Glu88Lys Ser80Phe + Asp84Tyr 64 64 32
9 1 Ser84Phe Ser80Phe Asp434Val 8 8 2
10 1 2 2 8
  1. CFX ciprofloxacin, LFX levofloxacin, MFX moxifloxacin