Table 6 Mutations in the quinolone resistance determining region (QRDR) and minimal inhibitory concentrations (MIC, μg/mL)
Mutation type | No. of isolates | Mutation | MIC (μg/mL) | |||||
|---|---|---|---|---|---|---|---|---|
gyrA | gyrB | parC | parE | CFX(≥ 4) | LFX(≥ 4) | MFX(≥ 2) | ||
1 | 7 | Ser84Phe | – | Ser80Tyr | – | 4 | 4 | 1 |
Ser84Phe | – | Ser80Tyr | – | 4 | 4 | 1 | ||
Ser84Phe | - | Ser80Tyr | - | 8 | 8 | 2 | ||
Ser84Phe | - | Ser80Tyr | - | 4 | 8 | 1 | ||
Ser84Phe | - | Ser80Tyr | - | 2 | 4 | 1 | ||
Ser84Phe | - | Ser80Tyr | - | 4 | 4 | 1 | ||
Ser84Phe | - | Ser80Tyr | - | 4 | 4 | 1 | ||
2 | 4 | Ser84Phe | – | Ser80Phe | – | 8 | 8 | 2 |
Ser84Phe | – | Ser80Phe | – | 16 | 8 | 1 | ||
Ser84Phe | – | Ser80Phe | – | 8 | 8 | 2 | ||
Ser84Phe | – | Ser80Phe | – | 8 | 8 | 2 | ||
3 | 3 | Ser84Phe | – | Ser80Phe + Asp84Val | – | 16 | 8 | 2 |
Ser84Phe | – | Ser80Phe + Asp84Val | – | 32 | 8 | 2 | ||
Ser84Phe | – | Ser80Phe + Asp84Val | – | 32 | 8 | 2 | ||
4 | 1 | Ser84Tyr | – | Ser80Ile | – | 32 | 8 | 2 |
5 | 1 | Ser84Tyr | – | Ser80Ile | Lys402Arg + Asn404Ile | 16 | 8 | 2 |
6 | 1 | Ser84Phe | – | Ser80Phe + Asp84Val | Lys403Thr + Asn404Asp | 16 | 8 | 2 |
7 | 1 | Ser84Phe | – | Ser80Phe + Asp84Val | Lys402Arg + Lys403Arg | 32 | 8 | 2 |
8 | 1 | Ser84Tyr + Glu88Lys | – | Ser80Phe + Asp84Tyr | – | 64 | 64 | 32 |
9 | 1 | Ser84Phe | – | Ser80Phe | Asp434Val | 8 | 8 | 2 |
10 | 1 | – | – | – | – | 2 | 2 | 8 |