Fluoroquinolone resistance of Staphylococcus epidermidis isolated from healthy conjunctiva and analysis of their mutations in quinolone-resistance determining region

Table 6 Mutations in the quinolone resistance determining region (QRDR) and minimal inhibitory concentrations (MIC, μg/mL)

Mutation type	No. of isolates	Mutation				MIC (μg/mL)
Mutation type	No. of isolates	gyrA	gyrB	parC	parE	CFX(≥ 4)	LFX(≥ 4)	MFX(≥ 2)
1	7	Ser84Phe	–	Ser80Tyr	–	4	4	1
		Ser84Phe	–	Ser80Tyr	–	4	4	1
		Ser84Phe	-	Ser80Tyr	-	8	8	2
		Ser84Phe	-	Ser80Tyr	-	4	8	1
		Ser84Phe	-	Ser80Tyr	-	2	4	1
		Ser84Phe	-	Ser80Tyr	-	4	4	1
		Ser84Phe	-	Ser80Tyr	-	4	4	1
2	4	Ser84Phe	–	Ser80Phe	–	8	8	2
		Ser84Phe	–	Ser80Phe	–	16	8	1
		Ser84Phe	–	Ser80Phe	–	8	8	2
		Ser84Phe	–	Ser80Phe	–	8	8	2
3	3	Ser84Phe	–	Ser80Phe + Asp84Val	–	16	8	2
		Ser84Phe	–	Ser80Phe + Asp84Val	–	32	8	2
		Ser84Phe	–	Ser80Phe + Asp84Val	–	32	8	2
4	1	Ser84Tyr	–	Ser80Ile	–	32	8	2
5	1	Ser84Tyr	–	Ser80Ile	Lys402Arg + Asn404Ile	16	8	2
6	1	Ser84Phe	–	Ser80Phe + Asp84Val	Lys403Thr + Asn404Asp	16	8	2
7	1	Ser84Phe	–	Ser80Phe + Asp84Val	Lys402Arg + Lys403Arg	32	8	2
8	1	Ser84Tyr + Glu88Lys	–	Ser80Phe + Asp84Tyr	–	64	64	32
9	1	Ser84Phe	–	Ser80Phe	Asp434Val	8	8	2
10	1	–	–	–	–	2	2	8

ISSN: 2047-2994