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Table 4 Bivariate and multivariate analyses factors associated with adherence to AL among uncomplicated P. falciparum malaria patients in AsgedeTsimbla district, Tigray, Ethiopia, 2018 (n = 384)

From: Artemether–lumefantrin treatment adherence among uncomplicated plasmodium falciparum malaria patients, visiting public health facilities in AsgedeTsimbla district, Tigray, Ethiopia: a cross-sectional study

Variable Adherence to AL COR
(95%CI)
P-value AOR (95%CI) P-value
Non-adhered
n (%)
Adhered
n (%)
Age group (years)  < 5 27 (15.2) 69 (33.5) 0.3 (0.1–0.52) 0.01 0.4 (0.2–0.88) 0.02*
  5 to 17 44 (24.7) 52 (25.2) 0.6 (0.4–1.1) 0.11 0.7 (0.3–1.41) 0.74
   ≥ 18 107 (60.1) 85 (41.3) 1   1  
Educational level Illiterate 108 (60.7) 53 (25.7) 15 (7.5–29.7) 0.01 9.4 (4.2–21.3) 0.01**
Primary (1–8 grade) 58 (32.6) 65 (31.6) 6.5 (3.2–13.1) 0.01 4.5 (1.9–10.2) 0.01**
Secondary and above 12 (6.7) 88 (42.7) 1   1  
Had radio/TV No 86 (48.3) 72 (35) 1.7 (1.1–2.6) 0.01 0.8 (0.4–1.5) 0.5
Yes 92 (51.7) 134 (65) 1   1  
Treatment given Health post 56 (31.5) 106 (51.5) 0.4 (0.2–0.65) 0.01 0.3 (0.1–0.55) 0.01**
Health center 122 (68.5) 100 (48.5) 1   1  
Improved during visit No 6 (3.4) 12 (6) 0.5 (0.2–1.5) 0.26 0.9 (0.2–3.4) 0.87
Yes 172 (96.6) 194 (94) 1   1  
Recalled side effect No 160 (90) 144 (70) 3.8 (2.1–6.7) 0.01 1.1 (0.4–2.5) 0.8
  Yes 18 (10) 62 (30) 1   1  
Knew consequences
of AL discontinued
No 174 (84.5) 78 (43.8) 6.9 (4.3–11.2) 0.01 4.0 (2.1–7.6) 0.01**
Yes 32 (15.5) 100 (56.2) 1   1  
Had AL bitter taste No 64 (36) 118 (57.3) 0.7 (0.4–1.0) 0.08 0.8 (0.4–1.4) 0.5
Yes 114 (64) 88 (42.3) 1   1  
Vomited within 30 min of ingestion Waited till the next dose 112 (62.9) 76 (36.9) 2.9 (1.9–4.3) 0.01 1.0 (0.5–1.9) 0.92
Repeated the dose 66 (37.1) 130(63.1) 1   1  
Improved before tablets got finished Stopped/saved drug 111 (62.4) 35 (17) 8.1 (5.0–13) 0.01 3.2 (1.7–5.9) 0.01**
Continued till finished 67 (37.6) 171 (83) 1   1  
Perceived preferred drug formulation Syrup 57 (32) 34 (16.5) 3.6 (2.1–6.1) 0.01 1.8 (0.9–4.2) 0.06
Injection 67 (37.6) 55 (26.7) 2.6 (1.6–4.2) 0.01 2 (0.9–4.2) 0.06
Tablets 54 (30.4) 117 (56.8) 1   1  
Concomitant drugs Yes 98 (55) 47 (22.8) 4.1 (2.6–6.4) 0.01 2.5 (1.4–4.5) 0.01**
No 80 (45) 159 (77.2) 1   1  
First dose taken At home 158 (88.8) 168 (81.6) 1.7 (0.9–3.2) 0.05 0.5 (0.2–1.2) 0.13
At health facility 20 (11.2) 38 (18.4) 1   1  
Prescribed drug instruction given Package as visual aid 82 (46.1) 102 (49.5) 0.7 (0.4–1.0) 0.11 1.0 (0.3–3.1) 0.87
Verbal with written 12 (6.7) 30 (14.6) 0.3 (0.1–0.73) 0.01 2 (0.7–5.9) 0.16
Verbal only 84 (47.2) 74 (35.9) 1   1  
Got chance to repeat prescription instruction No 151 (84.8) 134 (65) 3 (1.8–4.9) 0.12 1.8 (0.9–3.6) 0.06
Yes 27 (15.2) 72 (35) 1   1  
  1. *p-value < 0.05; **p-value < 0.01