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Table 2 Meta-analysis results using calculated unadjusted ORs

From: Burden of carbapenem non-susceptible infections in high-risk patients: systematic literature review and meta-analysis

Analysis for unadjusted mortality data

Studies (N)

Calculated OR (95% CI)

Totally high-risk patient populations

8

5.85 (3.69, 9.26); I2 = 19.8%

 Low risk of bias

6

5.07 (3.38, 7.59); I2 = 0.0%

 CS infection comparator

5

5.24 (2.65, 10.37); I2 = 32.1%

 No CR infection comparator

3

7.02 (3.33, 14.80); I2 = 18.4%

 No infection comparator

2

24.76 (4.14, 148.00); I2 = 71.4%

 In-hospital/≤30-day mortality

4

6.08 (3.83, 9.66); I2 = 0.0%

 Longer-term (> 30 days) mortality

5

6.56 (2.81, 15.33); I2 = 51.3%

 Italy

3

5.86 (3.65, 9.41); I2 = 0.0%

 USA

5

5.40 (2.58, 11.30); I2 = 34.1%

Partially and totally high-risk patient populations

14

4.13 (2.70, 6.31); I2 = 71.5%

 Low risk of bias

9

3.94 (2.32, 6.68); I2 = 71.4%

 CS infection comparator

10

3.39 (2.11, 5.45); I2 = 70.2%

 No CR infection comparator

3

7.02 (3.33, 14.80); I2 = 18.4%

 No infection comparator

3

13.39 (4.09, 43.87); I2 = 75.0%

 In-hospital/≤30-day mortality

10

3.74 (2.37, 5.89); I2 = 74.2%

 Longer-term (> 30 days) mortality

5

6.56 (2.81, 15.33); I2 = 51.3%

 CRKP studies only

12

4.68 (3.03, 7.23); I2 = 61.0%

 CRPA studies only

2

2.25 (0.84, 6.03); I2 = 77.6%

 Italy

5

4.21 (2.17, 8.14); I2 = 73.3%

 USA

9

3.83 (2.54, 5.76); I2 = 28.1%

  1. CI Confidence interval, CRKP Carbapenem-resistant Klebsiella pneumoniae, CRPA Carbapenem-resistant Pseudomonas aeruginosa, CS Carbapenem-susceptible, N Number, OR Odds ratio