Does vancomycin resistance increase mortality in Enterococcus faecium bacteraemia after orthotopic liver transplantation? A retrospective study

Table 3 Risk factors for death within 30 days after Enterococcus faecium bacteraemia (Cox regression; n = 177)

			Univariate			Multivariate
Variables	Dead n = 21	Alive n = 156	HR	95% CI	p	HR	95% CI	p
Definitive infectious focus elimination
Yes	6 (28.6)	40 (25.6)	0.85	0.33–2.20	0.745	0.50	0.19–1.37	0.181
No	15 (71.4)	116 (74.4)
Start of adequate AB Therapy within < 48 h post-BSI onset
Yes	14 (66.7)	90 (57.7)	1.47	0.59–3.64	0.407	1.03	0.39–2.74	0.952
No	7 (33.3)	66 (42.3)
Mean SOFA_Non-GCS (day-7 until day-1 before BSI onset)	12.8 ± 3.8	6.8 ± 4.7	1.30	1.16–1.46	< 0.001	1.32	1.14–1.53	< 0.001
ICU stay between day-7 and BSI onset [days]	7.6 ± 1.2	5.0 ± 3.5	1.47	1.08–2.00	0.014	1.01	0.71–1-44	0.966
Bacteraemia
VRE	6 (15.4)	33 (84.6)	1.49	0.58–3.84	0.409	1.80	0.64–5.03	0.264
VSE	15 (10.9)	123 (89.1)

Data are presented as n (%) or mean ± standard deviation.
Abbreviations: HR hazards ratio, CI confidence interval, AB antibiotic therapy, BSI bloodstream infection, SOFA sequential organ failure assessment, GCS Glasgow coma scale, VRE vancomycin-resistant Enterococcus faecium, VSE vancomycin-susceptible Enterococcus faecium

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