Table 1 Characteristics of studies included in the meta-analysis of the type 1 comparison
Study | Study design | Matching ratio | Matched factors | Enrollment period | Country | Setting | Sample size, CRKP infection/CSKP infection | Average age(SD or range),CRKP infection/CSKP infection | Sex (male), CRKP infection/CSKP infection | NOS points |
|---|---|---|---|---|---|---|---|---|---|---|
Gómez, 2014 [7] | Case-case-control | 1:1:2 | Length of stay in ICU and date of bacterial isolation | January 2008–January 2011 | Colombia | Single center | 61/61 | 42.2 ± 28.4/40.5 ± 28.2 | 30/44 | 8 |
Wu, 2011 [8] | Case-control | 1:2 | Site of infection and the date of hospital admission (± within 5 days) | July 2006–July 2008 | China | Single center | 39/78 | 64.0 ± 16.0/56.9 ± 17.6 | 28/60 | 7 |
Falagas, 2007 [9] | Case-control | 1:1 | Site of infection, age ± 5 years and length of hospital stay up to isolation of CRKP ±3 days and year of hospital admission | October 2000–May 2006 | Greece | Multicenter (2 hospitals) | 53/53 | 61.5 ± 18.8/61.9 ± 17.2 | 23/54 | 6 |
Patel, 2008 [20] | Case-control | 1:1 | Anatomic site of infection, age and date of isolation of K. pneumoniae | July 2004–June 2006 | USA | Single center | 99/99 | 60.67 ± 14.95/59.39 ± 13.34 | 58/58 | 7 |
Simkins, 2014 [21] | Case-control | NA | NA | January 2006–December 2010 | USA | Single center | 13/39 | 53 ± 18/55 ± 16 | 7/14 | 5 |
Hu, 2016 [22] | Case-control | 1:1 | Year of ICU admission and site of infection | January 2011–June 2013 | China | Single center, a 67-bed ICU | 65/65 | 64.12 ± 13.69/59.06 ± 14.61 | 45/50 | 6 |
Candevir, 2015 [23] | Retrospective cohort | NA | NA | January 2012–December 2012 | Turkey | Single center, ICUs | 47/51 | 38 (0–83)/8 (0–86) a | 31/30 | 7 |
Vardakas, 2015 [24] | Retrospective cohort | NA | NA | January 2006–October 2009 | Greece | Single center, an 8-bed ICU | 73/18 | 66.3 ± 14.4/60.9 ± 15.6 | 36/7 | 7 |
Correa, 2013 [25] | Case-control | 1:2 | Infection date, anatomic site of infection, and the unit where infection was acquired | January 2006–August 2008 | Brazil | Single center | 20/40 | 59.6/64.9 b | 13/21 | 7 |
X. Zheng, 2017 [26] | Case-control | NA | NA | January 2013–December 2014 | China | Single center, 30-bed medical ICU | 31/17 | 57.61 ± 14.78/62.71 ± 16.34 | 27/11 | 5 |
Zheng, 2017 [27] | Case-control | 1:1 | In the same ward during the same period (within 30 days) and ages within 5 years of each other | January 2013–July 2015 | China | Single center | 51/51 | 69.84 ± 18.0/67.25 ± 20.1 | 39/35 | 8 |
Shilo, 2013 [28] | Case-control | 1:1 | Hospitalized during the same year | January 2006–April 2009 | Israel | Single center | 135/127 | 77 ± 14/80 ± 13 | 62/53 | 7 |
Wang, 2018 [29] | Case-control | 1:1 | Admitted to the same department during the same time period | January 2010–December 2014 | China | Single center | 48/48 | 67.7 ± 19.5/63.1 ± 17.8 | 35/34 | 6 |
Mouloudi, 2010 [30] | Nested case-control | NA | NA | January 2007–December 2008 | Greece | Single center, 8-bed polyvalent ICU | 37/22 | NA | 28/17 | 6 |
Hussein, 2013 [31] | Case-control | NA | NA | January 2006–December 2008 | Israel | Single center | 103/214 | 61.4 ± 17/63.2 ± 18 | 73/133 | 7 |
Pan, 2019 [32] | Retrospective cohort | 1:2 | Age, sex, and specimen source | 2014 | China | Single center | 66/132 | 58.8 ± 15.9/57.4 ± 14.7 | 45/90 | 8 |
Tsereteli, 2018 [33] | Case-control | NA | NA | January 2017–February 2018 | Georgia | Multicenter (2 hospitals), ICUs | 20/26 | 52.3 ± 19.153/54.46 ± 18.591 | 18/16 | 6 |
Hoxha, 2016 [34] | Prospective cohort | 1:1 | Age (10 years), hospital, and type of specimen (blood/bronchoscopy specimen) | November 2012–July 2013 | Italy | Multicenter (10 Italian hospitals) | 49/49 | 72/74 c | 32/32 | 8 |