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Table 1 Characteristics of studies included in the meta-analysis of the type 1 comparison

From: Risk factors for carbapenem-resistant Klebsiella pneumoniae infection relative to two types of control patients: a systematic review and meta-analysis

StudyStudy designMatching ratioMatched factorsEnrollment periodCountrySettingSample size, CRKP infection/CSKP infectionAverage age(SD or range),CRKP infection/CSKP infectionSex (male), CRKP infection/CSKP infectionNOS points
Gómez, 2014 [7]Case-case-control1:1:2Length of stay in ICU and date of bacterial isolationJanuary 2008–January 2011ColombiaSingle center61/6142.2 ± 28.4/40.5 ± 28.230/448
Wu, 2011 [8]Case-control1:2Site of infection and the date of hospital admission (± within 5 days)July 2006–July 2008ChinaSingle center39/7864.0 ± 16.0/56.9 ± 17.628/607
Falagas, 2007 [9]Case-control1:1Site of infection, age ± 5 years and length of hospital stay up to isolation of CRKP ±3 days and year of hospital admissionOctober 2000–May 2006GreeceMulticenter (2 hospitals)53/5361.5 ± 18.8/61.9 ± 17.223/546
Patel, 2008 [20]Case-control1:1Anatomic site of infection, age and date of isolation of K. pneumoniaeJuly 2004–June 2006USASingle center99/9960.67 ± 14.95/59.39 ± 13.3458/587
Simkins, 2014 [21]Case-controlNANAJanuary 2006–December 2010USASingle center13/3953 ± 18/55 ± 167/145
Hu, 2016 [22]Case-control1:1Year of ICU admission and site of infectionJanuary 2011–June 2013ChinaSingle center, a 67-bed ICU65/6564.12 ± 13.69/59.06 ± 14.6145/506
Candevir, 2015 [23]Retrospective cohortNANAJanuary 2012–December 2012TurkeySingle center, ICUs47/5138 (0–83)/8 (0–86) a31/307
Vardakas, 2015 [24]Retrospective cohortNANAJanuary 2006–October 2009GreeceSingle center, an 8-bed ICU73/1866.3 ± 14.4/60.9 ± 15.636/77
Correa, 2013 [25]Case-control1:2Infection date, anatomic site of infection, and the unit where infection was acquiredJanuary 2006–August 2008BrazilSingle center20/4059.6/64.9 b13/217
X. Zheng, 2017 [26]Case-controlNANAJanuary 2013–December 2014ChinaSingle center, 30-bed medical ICU31/1757.61 ± 14.78/62.71 ± 16.3427/115
Zheng, 2017 [27]Case-control1:1In the same ward during the same period (within 30 days) and ages within 5 years of each otherJanuary 2013–July 2015ChinaSingle center51/5169.84 ± 18.0/67.25 ± 20.139/358
Shilo, 2013 [28]Case-control1:1Hospitalized during the same yearJanuary 2006–April 2009IsraelSingle center135/12777 ± 14/80 ± 1362/537
Wang, 2018 [29]Case-control1:1Admitted to the same department during the same time periodJanuary 2010–December 2014ChinaSingle center48/4867.7 ± 19.5/63.1 ± 17.835/346
Mouloudi, 2010 [30]Nested case-controlNANAJanuary 2007–December 2008GreeceSingle center, 8-bed polyvalent ICU37/22NA28/176
Hussein, 2013 [31]Case-controlNANAJanuary 2006–December 2008IsraelSingle center103/21461.4 ± 17/63.2 ± 1873/1337
Pan, 2019 [32]Retrospective cohort1:2Age, sex, and specimen source2014ChinaSingle center66/13258.8 ± 15.9/57.4 ± 14.745/908
Tsereteli, 2018 [33]Case-controlNANAJanuary 2017–February 2018GeorgiaMulticenter (2 hospitals), ICUs20/2652.3 ± 19.153/54.46 ± 18.59118/166
Hoxha, 2016 [34]Prospective cohort1:1Age (10 years), hospital, and type of specimen (blood/bronchoscopy specimen)November 2012–July 2013ItalyMulticenter (10 Italian hospitals)49/4972/74 c32/328
  1. Abbreviations: CRKP carbapenem-resistant Klebsiella pneumoniae, CSKP Carbapenem-susceptible Klebsiella pneumoniae, SD Standard deviation, NOS Newcastle-Ottawa Scale, ICU Intensive care unit, NA Not available
  2. aAge, median (range), years
  3. bAge, mean, years
  4. cAge, median, years