Table 2 Characteristics of studies included in the meta-analysis of the type 2 comparison
Study | Study design | Matching ratio | Matched factors | Period | Country | Setting | Sample size, CRKP infection/without CRKP infection | Average age (SD or range), CRKP infection/without CRKP infection | Sex (male), CRKP infection/without CRKP infection | NOS points |
|---|---|---|---|---|---|---|---|---|---|---|
Mouloudi, 2014 [37] | Prospective cohort | 1:2 | During the same period | January 2008–December 2011 | Greece | Single center, 8-bed polyvalent ICU | 17/34 | 54 (44–66)/55 (26–66)a | 10/19 | 5 |
Giannella, 2015 [38] | Prospective cohort | NA | NA | June 2010–December 2013 | Italy | Single center | 20/217 | 63 ± 2.8/55 ± 14 | 15/143 | 7 |
Akgul, 2016 [39] | Case-control | NA | At least 72 h in the same wards and period with the cases | January 2010–September 2014 | Turkey | Single center | 95/100 | 66 (19–94)/58 (21–87)a | 63/62 | 6 |
Giannella, 2014 [36] | Case–control | 1:4 | The time of the primary positive CRKP rectal swab (within the same month) and the time atrisk of having a subsequent infection | January 2012–December 2013 | Italy | Multicenter (5 large tertiary-care teachinghospitals) | 143/572 | 65 (52–75)/70 (58–81)a | 84/307 | 6 |
Borer, 2012 [35] | Case-control | 1:2 | Age within 5 years, same sex, time of admission ± 5 days, and similar length of time at risk ±2 days | May 2007–January 2010 | Israel | Single center | 42/84 | 72 (19–91)/72.5 (21–95)a | NA | 6 |
Yang, 2016 [40] | Case-control | 1:2 | Month of admission, ward, as well as interval days (interval from admission to confirmation of the index culture) | January 2012–December 2013 | China | Single center | 370/740 | 85 (80–87)/74 (59–84)a | 321/434 | 7 |
Micozzi, 2017 [41] | Retrospective cohort | NA | NA | 24 February 2012–31 May 2013 | Italy | Single center | 11/8 | NA | 5/8 | 5 |
Mazza, 2017 [42] | Retrospective cohort | NA | NA | January 2012–December 2015 | Italy | Single center | 8/302 | NA | NA | 6 |
Varotti, 2017 [43] | Case-control | 1:2 | The patient transplanted chronologically before and the patient transplanted chronologically after the study patient | January 2010–June 2015 | Italy | Single center | 26/52 | 59 ± 13/53 ± 14 | 21/43 | 8 |
Salsano, 2016 [44] | Retrospective cohort | NA | NA | January 2104–December 2014 | Italy | Single center | 32/521 | 74 (67–77)/71 (63–77)a | 17/362 | 6 |
Kontopoulou, 2019 [45] | Case-cohort | NA | NA | June 2011–August 2014 | Greece | Single center, 8-bed medical and surgical ICU | 48/178 | 60/63c | NA | 6 |
Gallagher, 2014 [46] | Case-case-control | 1:1 | Location (hospital unit) and time (within 30 days) | June 2005–October 2010 | USA | Single center | 43/43 | 56/58b | 26/26 | 6 |
Kalpoe, 2012 [47] | Retrospectivecohort | NA | NA | 1 January 2005–1 October 2006 | USA | Single center | 14/161 | 57 (52–71)/55 (23–78)a | 9/133 | 6 |
Akturk, 2016 [48] | Case-control | NA | NA | January 2010–December2014 | Turkey | Single center, pediatric and neonatal ICUs | 24/61 | 53 ± 14.7/23.5 ± 5.8 | NA | 6 |