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Table 3 Clinical manifestations of the 24 patients colonized with CRE

From: Different screening frequencies of carbapenem-resistant Enterobacteriaceae in patients undergoing hematopoietic stem cell transplantation: which one is better?

Pt

Age /Sex

Disease/HSCT

CRE Isolate

Which times screening turned positive

Febrile episodes in carriers

Time from colonization to fever (day)

Time from fever to the use of tigecycline (hour)

ANC at fever (×109/L)

Symptoms at fever

CRP (mg/L) /PCT (ug/L)

30 days status

Single screening

1a

36/F

ALL/Haplo

E.coli

/

Yes

−3

> 72

0

Abdominal pain, diarrhoea

216.8/1.0

Dead

2

56/F

MM/Auto

E. coli

1

Yes

7

< 24

0

Chills, tremble

95.1/4.1

Alive

3

32/m

ALL/MUD

K.pneumoniae

1

Yes

5

< 24

0

No

48.9/normal

Alive

Continuous screening

4

36/M

AML/Haplo

K.pneumoniae

5

No

/

/

/

/

/

Alive

5

15/M

AML/Haplo

E. coli

2

Yes

9

< 24

0

Chills, tremble

73.0/normal

Alive

6

27/M

ALL/Haplo

E. coli

3

Yes

8

< 24

0

No

52.2/normal

Alive

7

48/M

AML/Haplo

E.coli

2

Yes

4

< 24

0

Perianal inflammation

112.3/ normal

Alive

8

45/M

AML/Haplo

K.pneumoniae

4

No

/

/

/

/

/

Alive

9

40/M

AL/Haplo

K.pneumoniae

1

No

/

/

/

/

/

Alive

10

38/M

T-LBL/Haplo

E. coli

3

Yes

11

< 24

0.5

No

43.2/normal

Alive

11

16/F

ALL/Haplo

E. coli

1

Yes

17

< 24

0

No

54.2/normal

Alive

12

18/M

ALL/MUD

E.coli

2

Yes

9

< 24

0

Chills, tremble

64.5/normal

Alive

13

25/M

ALL/Haplo

E.coli

2

Yes

8

< 24

0

No

61.2/normal

Alive

14

34/F

AML/Haplo

K.pneumoniae

3

No

/

/

/

/

/

Alive

15

44/M

MM/Auto

E.coli

4

No

/

/

/

/

/

Alive

16

50/M

AML/Sib

K.pneumoniae

1

Yes

15

< 24

0

sore throat

70.4/normal

Alive

17

18/M

ALL/Haplo

K.pneumoniae

5

No

/

/

/

/

/

Alive

18

51/M

ALL/Haplo

E.coli

5

No

/

/

/

/

/

Alive

19

22/M

ALL/Haplo

K.pneumoniae

4

No

/

/

/

/

/

Alive

20

22/F

AML/Haplo

K.pneumoniae

3

Yes

1

> 48

0

Chills, tremble

65.2/0.6

Alive

21

26/M

ALL/MUD

K.pneumoniae

1

Yes

13

< 24

0

No

73.4/normal

Alive

22

27/M

ALL/Haplo

K.pneumoniae

6

No

/

/

/

/

/

Alive

23

21/M

AML/Haplo

K.pneumoniae

2

Yes

12

< 24

0

Perianal

inflammation

307/ normal

Alive

24

62/M

AML/Haplo

K.pneumoniae

6

Yes

2

< 24

0

No

141.7/normal

Alive

  1. Abbreviations: AML Acute myeloid leukemia, ALL Acute lymphatic leukemia, AL Acute leukemia, Auto Autologous HSCT, CRP C-reactive protein (normal value: 0-8 mg/L)E.coli Escherichia coli, Haplo HLA-Haploidentical allogeneic HSCT, K.pneumoniae Klebsiella pneumoniae, MM Multiple myeloma, MUD Matched-unrelated donor allogeneic HSCT, PCT Procalcitonin (normal value:< 0.5μg/L), Sib HLA-sibling allogeneic HSCT, T-LBL T-lymphoblastic lymphoma
  2. aThe patient 1:single screening was negative for the patient, but subsequent screening indicated positive 3 days after the onset of fever and the patient died of septic shock
  3. 1.Four patients (2,12,20,23) were combined with polymyxin because of persistent fever after 48 h of tigecycline treatment, one of them (patient 20) developed CRE BSIs later
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Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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