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Table 3 Resistance rates (%) of major gram-negative bacteria of PBM patients in China, 2016–2018

From: Prevalence and antimicrobial resistance patterns of bacteria isolated from cerebrospinal fluid among children with bacterial meningitis in China from 2016 to 2018: a multicenter retrospective study

Antimicrobial agent Eco
A/B (%)
Kpn
A/B (%)
Aba
A/B (%)
Pae
A/B (%)
Ampicillin 105/125 (84.0) 25/26 (96.2) 14/18 (77.8) 12/13 (92.3)
Piperacillin 56/68 (82.4) 11/14 (78.6) 3/5 (60.0) 5/13 (38.5)
Cefazolin 52/104 (50.0) 18/23 (78.3)
Cefuroxime 11/21 (52.4) 4/8 (50.0)
Cefoxitin 0/30 (0) 5/8 (62.5)
Ceftriaxone 44/89 (49.4) 10/15 (66.7) 8/15 (53.3)
Cefotaxime 30/61 (49.2) 14/20 (70.0) 5/8 (62.5)
Ceftazidime 38/140 (26.4) 20/32 (62.5) 8/21 (38.1) 5/16 (31.2)
Cefepime 45/140 (32.1) 17/32 (53.1) 7/21 (33.3) 3/17 (17.6)
Amoxicillin/clavulanic acid 8/13 (61.5)
Ampicillin/Sulbactam 58/102 (56.9) 20/26 (76.9) 5/15 (33.3) 7/7 (100)
Piperacillin/tazobactam 3/122 (2.5) 20/30 (66.7) 5/12 (41.7) 4/10 (40.0)
Cefoperazone/sulbactam 1/17 (5.9)
Tobramycin 23/56 (41.1) 2/8 (25.0) 1/10 (10.0) ¼ (25.0)
Gentamicin 49/127 (38.6) 13/30 (43.3) 5/19 (41.7) 2/13 (15.4)
Amikacin 0/142 (0) 11/31 (35.5) 2/16 (12.5) 1/16 (6.2)
Ciprofloxacin 73/131 (55.7) 12/29 (41.4) 5/20 (25.0) 1/13 (7.7)
Levofloxacin 74/138 (53.6) 12/32 (37.5) 5/21 (23.8) 3/16 (18.8)
Aztreonam 43/124 (34.7) 17/26 (65.4) 2/4 (50.0)
Tetracycline 60/76 (78.9) 9/30 (30.0) 5/9 (55.6)
Co-trimoxazole 97/141 (68.8) 5/34 (14.7) 13/22 (59.1)
Meropenem 6/88 (6.8) 16/25 (64.0) 6/11 (54.5) 2/13 (15.4)
Ertapenem 0/79 (0) 1/12 (8.3)
Imipenem 4/140 (2.9) 5/22 (22.7) 6/19 (31.6) 6/16 (37.5)
  1. PBM, pediatric bacterial meningitis; Eco, Escherichia coli; Kpn, Klebsiella pneumoniae; Aba, Acinetobacter baumannii; Pae, Pseudomonas aeruginosa
  2. A/B (%), number resistant/number tested (percentage resistant)
  3. A dash (–) indicates that antibiotics were not tested against the isolated pathogens
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