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Table 6 Amino acid substitution profiles for ciprofloxacin-resistant E. coli (n = 40)

From: Genetic mechanisms and correlated risk factors of antimicrobial-resistant ESKAPEE pathogens isolated in a tertiary hospital in Malaysia

Target gene

Amino acid substitution profile*

No. (%) of strains

gyrA

Ser-83-Leu; Asp-87-Asn; Leu-102-Ala

4 (10)

Ser-83-Leu; Asp-87-Tyr; Gly-105-Val

2 (5)

Ser-83-Leu; Asp-87-Asn

14 (35)

Ser-83-Leu

6 (15)

gyrB

None

37 (93)

parC

Ser-80-Ile; Glu-84-Ile

7 (18)

Ser-80-Ile

16 (40)

parE

Ser-458-Ala

2 (5)

  1. *Ala: alanine; Asp: aspartate; Asn: asparagine; Glu: glutamate; Gly: glycine; Ile: Isoleucine; Leu: leucine; Ser: serine; Tyr: tyrosine; Val: valine