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Table 3 The effect of recombinant mcr-3 variant expression on colistin MIC, based on BMD

From: Characterisation of mobile colistin resistance genes (mcr-3 and mcr-5) in river and storm water in regions of the Western Cape of South Africa

Isolates

Colistin BMD MIC (mg/L)

E. coli ATCC 25922 (susceptible control)

0.5

E. coli NCTC® 13846 (mcr-1 control)

4

E. coli SHuffle T7

0.5

E. coli SHuffle T7 transformed with:

pET-48b(+)

0.5

pET-48b(+)-mcr-1

4

pET-48b(+)-mcr-3.33

4

pET-48b(+)-mcr-3.34

4

pET-48b(+)-mcr-3.35

4

pET-48b(+)-mcr-3.36

4

pET-48b(+)-mcr-3.37

4

  1. MIC ≤ 2 mg/L: susceptible, MIC > 2 mg/L: resistant