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Table 1 Prevalence of VRSA in S. aureus and VRSA in MRSA based on quality, continent, countries, isolate source, and AST method

From: Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates

Subject Sub group No. studies No. strains Proportion (95% CI) %Weight P I2 P sig
Overall VRSA 62 12,816 0.06 (0.04, 0.09) 100 0 0.9574 0
VRSA from MRSA 25 3925 0.06 (0.03, 0.09) 100 0 0.9366 0
Quality         
High quality VRSA 43 10,990 0.05 (0.03, 0.07) 70.83 0 0.9599 0
VRSA from MRSA 19 3390 0.07 (0.03, 0.12) 68.85 0 0.9531 0
Low quality VRSA 19 1826 0.1 (0.04, 0.17) 28.68 0 0.9460 0
VRSA from MRSA 9 675 0.02 (0.01, 0.05) 31.15 0.03 0.5328 0
Continent         
Asia VRSA 46 11,074 0.05 (0.03, 0.08) 75.03 0 0.9555 0
VRSA from MRSA 22 3416 0.06 (0.03, 0.11) 82.07 0 0.9443 0
South America VRSA 2 171 0.03 (0.00, 0.17) 1.39    0.16
VRSA from MRSA       
Africa VRSA 7 720 0.16 (0.03, 0.35) 11.20 0 0.9706 0
VRSA from MRSA 1 50 0.00 (0.00, 0.07) 3.06    0
America VRSA 3 395 0.04 (0.02, 0.07) 6.48 0.23 0.3054 0
VRSA from MRSA 2 272 5(0.03, 0.08) 8.08    1
Europe VRSA 4 456 0.01 (0, 0.05) 5.90 0.03 0.6616 0.14
VRSA from MRSA 2 187 0 (0, 0.02) 6.19    0.87
Countries         
Pakistan VRSA 5 934 0.1 (0.01, 0.24) 8.40 0 0.9693 0.01
VRSA from MRSA 3 301 0.07 (0, 0.25) 11.61    0.06
India VRSA 14 5647 0.07 (0.03, 0.13) 23.42 0 0.9778 0
VRSA from MRSA 6 3529 0.06 (0, 0.18) 23.50 0.01 0.98 0.03
Brazil VRSA 3 203 0.03 (0.01, 0.07) 4.48 0.00 0 0
VRSA from MRSA 1 140 0.04 (0.01, 0.08) 4.08    0
Nigeria VRSA 2 273 0.29 (0.24, 0.35) 3.30    0
VRSA from MRSA       
Iran VRSA 16 3464 0.02 (0.01, 0.04) 26.28 0 0.7848 0
VRSA from MRSA 6 875 0.04(0.01, 0.08) 23.20 0.01 67.03  
Algeria VRSA 3 583 0.01 (0, 0.04) 1.72    0.01
VRSA from MRSA 1 220 0.02 (0, 0.05) 4.08    0.01
USA VRSA 2 363 0.04 (0.02, 0.07) 3.39    0
VRSA from MRSA 1 132 0.08 (0.04, 0.13) 3.66    0
Italy VRSA 3 448 0.02 (0, 0.05) 5.03    0.02
VRSA from MRSA 1 179 0.01 (0, 0.04) 4.10    0.03
Saudi Arabia VRSA 2 128 0.18 (0.12, 0.26) 3.02    0
VRSA from MRSA 1 98 0.15 (0.09, 0.24) 3.95    0
Tanzania VRSA 1 53 0.11 (0.04, 0.23) 1.53    0
VRSA from MRSA . (.,.)     
Egypt VRSA 4 394 0.16 (0.01, 0.45) 6.36 0 0.9719 0.02
VRSA from MRSA 1 50 0 (0, 0.07) 3.66    1
Turkey VRSA 5 469 0.05 (0, 0.14) 7.65 0 0.8895 0.02
VRSA from MRSA 3 245 0.04 (0, 0.13) 9.56    0.1
Bangladesh VRSA 2 73 0.12 (0.05, 0.21) 2.86    0
VRSA from MRSA 2 73 0.27 (0.13, 0.43) 5.76    0
Germany VRSA 1 8 0.13 (0, 0.53) 0.87    0.15
VRSA from MRSA 1 8 0.13 (0, 0.53) 2.09    0.15
Jordan VRSA 1 139 0.04 (0.01, 0.08) 1.68    0
VRSA from MRSA . (.,.)     
Isolate source         
Clinical VRSA 53 11,891 0.06 (0.04, 0.08) 84.56 0 0.9582 0
VRSA from MRSA 23 5779 0.06 (0.03, 0.10) 85.92 0 0.9420 0
Clinical, non-clinic VRSA 4 501 0.14 (0.00, 0.44) 06.54 0 0.9815 0.04
VRSA from MRSA 1 179 0.01 (0.00, 0.04) 04.10    0.03
Non-clinical VRSA 6 424 0.07 (0.01, 0.15) 8.91 0 0.8615 0
VRSA from MRSA 3 245 0.04 (0.00, 0.13) 9.98    0.10
AST method(s)         
MIC-base VRSA 25 5671 0.07 (0.04, 0.12) 39.87 0 0.9599 0
VRSA from MRSA 9 1223 0.09 (0.03, 0.17) 30.99 0 0.874 0
Mixed-methods VRSA 32 6596 0.04 (0.02, 0.07) 51.95 0 0.9527 0
VRSA from MRSA 17 4995 0.04 (0.01, 0.09) 64.48 0 0.9538 0
Disk diffusion VRSA 33 6736 0.12 (0.02, 0.27) 8.18 0 0.9532 0
VRSA from MRSA 1 85 0.05 (0.01, 0.17) 3.52    0.03
  1. I2: the percentage of variance in a meta-analysis that shows study heterogeneity. VRSA: Vancomycin-resistant Staphylococcus aureus. MRSA: Methicillin-resistant Staphylococcus aureus. AST: Antimicrobial Susceptibility Testing. MIC: minimum inhibitory concentration