Comparison of colistin-induced nephrotoxicity between two different formulations of colistin in critically ill patients: a retrospective cohort study

Table 2 Clinical characteristics of ICU patients with and without the occurrence of KDIGO 3 acute kidney injury^a

	≥ KDIGO 3 AKI		P-value
	Yes, n = 41	No, n = 154	P-value
Age, years (SD)	71.4 (12.2)	74.4 (13.8)	0.138
Sex			0.421
Male	26 (63.4%)	112 (72.7%)
Female	15 (36.6%)	42 (27.3%)
BMI (SD)	22.2 (5.6)	22.3 (4.3)	0.788
Smoking	15 (36.6%)	63 (40.9%)	0.363
Comorbidities
Diabetes	12 (29.5%)	45 (29.2%)	0.958
Malignancies	10 (24.4%)	23 (14.9%)	0.243
Renal insufficiency	6 (14.6%)	15 (9.7%)	0.211
Chronic liver diseases	3 (7.3%)	13 (8.4%)	1.000
Heart failure	3 (7.8%)	14 (9.1%)	0.767
CR-GNB culture sources			0.035
Respiratory specimens	39 (95.1%)	118 (76.6%)
Urine	0	10 (6.5%)
Blood	2 (4.9%)	9 (5.8%)
Others^b	0	17 (11.0%)
CR-GNB species			0.229
CRAB	34 (82.9)	107 (69.5%)
CRE	6 (14.6%)	39 (25.3%)
CRPA	1 (2.4%)	8 (5.2%)
Laboratory results (Mean, SD)
Leukocytes (× 10⁹ per L)	11.5 (9.9)	13.7 (8.8)	0.183
CRP (mg/dL)	10.5 (10.0)	9.8 (5.6)	0.555
Albumin level	2.8 (2.5–3.1)	2.7 (2.4–3.0)	0.217
Concomitant nephrotoxins
Aminoglycoside	5 (12.2%)	17 (11.0%)	0.835
Vancomycin	8 (19.5%)	12 (7.8%)	0.028
Intravenous contrast agent	9 (22%)	30 (19.5%)	0.725
Disease severities
APACHEII scores (median, IQ R)^c	23 (18–31)	25 (20–30)	0.454
Respiratory failure^d	40 (97.6%)	135 (87.7%)	0.081
Septic shock^d	22 (53.7)	39 (25.3%)	0.001
Colistin treatment
Daily dose (MIU) (median, IQR)	8 (7.4–10)	8 (4–10)	0.036
Treatment duration (days) (median, IQR)	7 (4–11)	7 (4–12)	0.403
Accumulated dose (MIU) (median, IQR)	46.5 (30.5–87.2)	48 (24–80)	0.594
Inappropriate colistin dose	9 (22.0%)	14 (9.1%)	0.023

APACHE II Acute Physiology and Chronic Health Evaluation II, BMI body mass index, ICU intensive care unit, IQR interquartile range, CCr creatinine clearance, CR-GNB carbapenem-resistant gram-negative bacteria, SD standard deviation
^aData are presented as n (%)
^bIncluding abscess, ascites, CSF, and pericardial effusion
^cEvaluated on the day of ICU admission
^dPresent on the day of sample collection

ISSN: 2047-2994