Correlation between antibiotic consumption and the incidence of healthcare facility-onset Clostridioides difficile infection: a retrospective chart review and analysis

Table 2 Correlation analysis between antibiotic consumption and the incidence of HO-CDI with 1-month interval matching

Class of antibiotics	DDD		DOT
Class of antibiotics	Spearman ρ	P value	Spearman ρ	P value
Total	− 0.27	0.22	− 0.26	0.23
BLBLIs	0.36	0.10	0.40	0.06
Third-generation cephalosporins	− 0.35	0.10	− 0.28	0.20
Fourth-generation cephalosporins	− 0.26	0.22	− 0.25	0.25
Fluoroquinolones	0.03	0.89	− 0.12	0.58
Carbapenems	− 0.04	0.84	− 0.15	0.49
Glycopeptides	− 0.48	0.02*	− 0.45	0.03*
Tigecycline	0.17	0.43	0.18	0.40
Clindamycin	− 0.44	0.04*	− 0.49	0.02*

BLBLI β-lactam/β-lactam inhibitor, DDD defined daily dose, DOT days of therapy, HO-CDI healthcare facility-onset C. difficile infection
*P < 0.05

ISSN: 2047-2994