Table 5 Clinical outcomes of patients infected with resistance to both BDQ and LZD
Patient ID | Patient category | Drug susceptibility | Mutation conferring BDQ resistance | Mutation conferring LZD resistance | Treatment regimen | Sputum culture conversion | Clinical outcome |
|---|---|---|---|---|---|---|---|
040,012 | Previously treated | MDR | WT | Cys154Arg (rplC) | Bdq/Lzd/Mfx/Cs/Am/Pto | 8 weeks | Cured |
010,121 | Previously treated | XDR | Ile108Thr (Rv0678) | WT | Bdq/Lzd/Mfx/Cs/Cfz/Am | NA | Treatment failure |