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Table 3 S. aureus and E. faecium susceptibility patterns for selected antibiotics per year

From: The epidemiology of bloodstream infections and antimicrobial susceptibility patterns in Thuringia, Germany: a five-year prospective, state-wide surveillance study (AlertsNet)

 

2015

2016

2017

2018

2019

OR (95% CI)

p value

S. aureus

Oxacillin/Methicillin

608/63

(10.4)

772/48

(6.2)

818/33

(4.0)

933/50

(5.4)

824/21

(2.5)

0.74 (0.66; 0.83) < 0.001

Rifampicin

550/2

(0.4)

598/4

(0.7)

510/10

(1.9)

735/2

(0.3)

597/5

(0.8)

1.05 (0.81; 1.37) 0.71

Fluoroquinolones

608/190

(31.3)

767/186

(24.3)

813/167

(20.5)

800/144

(18.0)

627/126

(20.1)

0.81 (0.76; 0.87) < 0.001

E. faecium

Vancomycin

227/38

(16.7)

227/68

(30.0)

215/68

(31.6)

228/97

(42.5)

186/50

(26.9)

1.19 (1.08; 1.31) < 0.001

Teicoplanin

186/32

(17.2)

184/49

(26.6)

150/42

(28.0)

196/56

(28.6)

156/22

(14.1)

0.99 (0.88; 1.12) 0.92

Linezolid

220/3

(1.4)

219/2

(0.9)

205/4

(2.0)

222/20

(9.0)

185/5

(2.7)

1.50 (1.19; 1.90) < 0.001

Daptomycin

7/1

(14.3)

16/2

(12.5)

24/2

(8.3)

32/3

(9.4)

48/8

(16.7)

1.08 (0.74; 1.57) 0.71

Tigecycline

149/1

(0.7)

159/1

(0.6)

190/2

(1.1)

213/1

(0.5)

161/6

(3.7)

1.79 (0.89; 3.62) 0.10

  1. Number of tested isolates/number of resistant isolates (% resistant). The right column displays the results from the logistic regression with GEE as odds ratio (OR) for resistance for the unadjusted linear predictor year (i.e. OR per year) with 95% confidence interval (95% CI) and corresponding two-sided p value