Risk factors for colonization with multiple species of extended-spectrum beta-lactamase producing Enterobacterales: a case-case–control study

Table 3 Univariable analyses of potential predictors of shift of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) – comparison of case group 2^a and matched control group 3^a

	Univariable analyses
	OR	95%CI	p-value
Age	0.99	0.96–1.02	0.433
Female sex	0.82	0.30–2.23	0.701
Admission from nursing-home/long-term healthcare	0.75	0.08–6.71	0.797
Admission from other acute care facility	6.02	1.15–31.49	0.033
Recent hospitalization^b	0.78	0.26–2.29	0.649
Recent ICU stay^b	0.57	0.12–2.77	0.485
Travel^b	2.01	0.28–15.43	0.477
Hospitalization abroad^b	3.00	0.19–47.96	0.437
Charlson Comorbidity Index	0.98	0.77–1.26	0.934
Solid organ transplantation	1.26	0.20–8.03	0.809
Urinary catheterization^c	0.68	0.20–2.30	0.536
Recent surgery^e	0.74	0.26–2.11	0.579
Active open wounds^f	1.59	0.43–5.82	0.483
Prior antibiotic therapy^g	1.29	0.48–3.47	0.612
Immunosuppressive therapy^b	0.54	0.16–1.84	0.322
Proton-pump inhibitor therapy^g	0.97	0.33–2.87	0.963
Antibiotic use between hospitalizations	1.84	0.50–6.80	0.360
Duration of antibiotic therapy	1.00	0.99–1.00	0.295
Travel between hospitalizations	0.56	0.06–4.78	0.593
Hospitalization abroad	1.30	0.12–14.51	0.830

Bold represents statistically significant (p-values ≤ 0.05)
^aGroup 2 = patients with shift of ESBL-PE species between hospitalizations, Group 3 = control patients with colonization of one species of ESBL-PE within different hospitalizations
^bWithin the past 12 months
^cTransurethral or suprapubic within 30 days prior to index sample
^dIn place for at least 7 days prior to index sample
^eWithin the past 6 months
^fDiabetic ulcers, decubitus ulcers, or other draining wounds
^gWithin 3 months prior to index sample

ISSN: 2047-2994