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Table 3 Incidence Rate Ratio and associated percent changes for an interrupted time series analysis model of the VRE acquisition and incidence of MDROs in the MICU during the study periods

From: Real-world experience of how chlorhexidine bathing affects the acquisition and incidence of vancomycin-resistant enterococci (VRE) in a medical intensive care unit with VRE endemicity: a prospective interrupted time-series study

  Final multivariable modela
Regression coefficient (95% CI) p-valueb IRR (95% CI) Percent changec (95% CI)
Rectal VRE acquisition detected according to weekly surveillance
 Intercept (β0) − 4.029 (− 4.655 to − 3.436) < 0.001 0.018 (0.010 to 0.032) − 98.2 (− 99 to − 96.8)
 Pre-intervention slope (β1) 0.008 (− 0.022 to 0.038) 0.065 1.008 (0.978 to 1.039) 0.8 (− 2.2 to 3.9)
 Intervention level change (β2) − 0.868 (− 1.721 to − 0.074) 0.038 0.420 (0.179 to 0.929) − 58.0 (− 82.1 to − 7.1)
 Intervention slope change (β3) − 0.007 (− 0.061 to 0.048) 0.812 1.004 (0.899 to 1.120) 0.4 (− 10.1 to 12)
MDROs prevalence in clinical cultures
 VRE     
  Intercept (β0) − 5.572 (− 6.905 to − 4.379) < 0.001 0.004 (0.001 to 0.013) − 99.6 (− 99.9 to − 98.7)
  Pre-intervention slope (β1) 0.015 (− 0.046 to 0.076) 0.629 1.015 (0.955 to 1.079) 1.5 (− 4.5 to 7.9)
  Intervention level change (β2) − 1.248 (− 3.334 to 0.442) 0.183 0.287 (0.036 to 1.556) − 71.3 (− 96.4 to 55.6)
  Intervention slope change (β3) − 0.201 (− 0.148 to 0.106) 0.744 0.979 (0.862 to 1.112) − 2.1 (− 13.8 to 11.2)
 MRSA     
  Intercept (β0) − 5.070 (− 6.184 to − 4.084) < 0.001 0.006 (0.002 to 0.018) − 99.4 (− 99.8 to − 98.2)
  Pre-intervention slope (β1) − 0.019 (− 0.081 to 0.412) 0.542 0.981 (0.924 to 1.043) − 1.9 (− 7.6 to 4.3)
  Intervention level change (β2) 0.719 (− 0.064 to 0.096) 0.238 2.053 (0.621 to 6.785) 105.3 (− 6.2 to 578.5)
  Intervention slope change (β3) 0.015 (− 0.163 to 0.184) 0.704 1.016 (0.938 to 1.100) 1.6 (− 6.2 to 10.0)
 CRAB     
  Intercept (β0) − 3.741 (− 4.490 to − 3.042) < 0.001 0.024 (0.012 to 0.049) − 97.6 (− 98.8 to − 95.1)
  Pre-intervention slope (β1) − 0.021 (− 0.061 to 0.019) 0.310 0.980 (0.941 to 1.020) − 2.0 (− 5.9 to 2.0)
  Intervention level change (β2) 0.580 (− 0.325 to 1.491) 0.208 1.785 (0.724 to 4.403) 78.5 (− 27.6 to 340.3)
  Intervention slope change (β3) 0.004 (− 0.054 to 0.064) 0.886 1.004 (0.947 to 1.065) 0.4 (− 5.3 to 6.5)
  1. CI, confidence interval; IRR, incidence rate ratio; CRAB, carbapenem-resistant Acinetobacter baumannii; MDRO, multidrug-resistant organism; MICU, medical intensive care unit; MRSA, methicillin-resistant S. aureus; VRE, vancomycin-resistant enterococci
  2. aFinal multivariable model includes the use of mechanical ventilator as confounding parameters
  3. bInterrupted time series with segmented Poisson regression model
  4. c(IRR − 1) × 100