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Table 3 Incidence Rate Ratio and associated percent changes for an interrupted time series analysis model of the VRE acquisition and incidence of MDROs in the MICU during the study periods

From: Real-world experience of how chlorhexidine bathing affects the acquisition and incidence of vancomycin-resistant enterococci (VRE) in a medical intensive care unit with VRE endemicity: a prospective interrupted time-series study

 

Final multivariable modela

Regression coefficient (95% CI)

p-valueb

IRR (95% CI)

Percent changec (95% CI)

Rectal VRE acquisition detected according to weekly surveillance

 Intercept (β0)

− 4.029 (− 4.655 to − 3.436)

< 0.001

0.018 (0.010 to 0.032)

− 98.2 (− 99 to − 96.8)

 Pre-intervention slope (β1)

0.008 (− 0.022 to 0.038)

0.065

1.008 (0.978 to 1.039)

0.8 (− 2.2 to 3.9)

 Intervention level change (β2)

− 0.868 (− 1.721 to − 0.074)

0.038

0.420 (0.179 to 0.929)

− 58.0 (− 82.1 to − 7.1)

 Intervention slope change (β3)

− 0.007 (− 0.061 to 0.048)

0.812

1.004 (0.899 to 1.120)

0.4 (− 10.1 to 12)

MDROs prevalence in clinical cultures

 VRE

    

  Intercept (β0)

− 5.572 (− 6.905 to − 4.379)

< 0.001

0.004 (0.001 to 0.013)

− 99.6 (− 99.9 to − 98.7)

  Pre-intervention slope (β1)

0.015 (− 0.046 to 0.076)

0.629

1.015 (0.955 to 1.079)

1.5 (− 4.5 to 7.9)

  Intervention level change (β2)

− 1.248 (− 3.334 to 0.442)

0.183

0.287 (0.036 to 1.556)

− 71.3 (− 96.4 to 55.6)

  Intervention slope change (β3)

− 0.201 (− 0.148 to 0.106)

0.744

0.979 (0.862 to 1.112)

− 2.1 (− 13.8 to 11.2)

 MRSA

    

  Intercept (β0)

− 5.070 (− 6.184 to − 4.084)

< 0.001

0.006 (0.002 to 0.018)

− 99.4 (− 99.8 to − 98.2)

  Pre-intervention slope (β1)

− 0.019 (− 0.081 to 0.412)

0.542

0.981 (0.924 to 1.043)

− 1.9 (− 7.6 to 4.3)

  Intervention level change (β2)

0.719 (− 0.064 to 0.096)

0.238

2.053 (0.621 to 6.785)

105.3 (− 6.2 to 578.5)

  Intervention slope change (β3)

0.015 (− 0.163 to 0.184)

0.704

1.016 (0.938 to 1.100)

1.6 (− 6.2 to 10.0)

 CRAB

    

  Intercept (β0)

− 3.741 (− 4.490 to − 3.042)

< 0.001

0.024 (0.012 to 0.049)

− 97.6 (− 98.8 to − 95.1)

  Pre-intervention slope (β1)

− 0.021 (− 0.061 to 0.019)

0.310

0.980 (0.941 to 1.020)

− 2.0 (− 5.9 to 2.0)

  Intervention level change (β2)

0.580 (− 0.325 to 1.491)

0.208

1.785 (0.724 to 4.403)

78.5 (− 27.6 to 340.3)

  Intervention slope change (β3)

0.004 (− 0.054 to 0.064)

0.886

1.004 (0.947 to 1.065)

0.4 (− 5.3 to 6.5)

  1. CI, confidence interval; IRR, incidence rate ratio; CRAB, carbapenem-resistant Acinetobacter baumannii; MDRO, multidrug-resistant organism; MICU, medical intensive care unit; MRSA, methicillin-resistant S. aureus; VRE, vancomycin-resistant enterococci
  2. aFinal multivariable model includes the use of mechanical ventilator as confounding parameters
  3. bInterrupted time series with segmented Poisson regression model
  4. c(IRR − 1) × 100
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Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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