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Table 9 Clinical-evaluation, Kirby-Bauer AST result and empirical treatment of participants with E. coli or K. pneumoniae

From: Prevalence and characterization of antimicrobial resistance among gram-negative bacteria isolated from febrile hospitalized patients in central Ethiopia

Participant No Bacterial isolate Resistance against Clinical diagnosis Empirical antibiotic treatment Effectiveness of antibiotic treatment
3GC Fluoroquinolones Gentamicin
20 E. coli Yes Yes No UTI Ciprofloxacin Ineffective*
56 E. coli Yes No Yes RTI Ceftriaxone, cloxacillin Effective
258 E. coli No Yes Yes AFI None
259 E. coli Yes Yes Yes AFI None
264 E. coli Yes No No SSTI Ceftriaxone, metronidazole Ineffective
272 E. coli Yes Yes Yes SSTI Cloxacillin Ineffective
275 E. coli Yes No No SSTI Ceftriaxone, metronidazole Ineffective
351 E. coli Yes Yes Yes SSTI Ceftriaxone metronidazole Ineffective
411 E. coli Yes Yes Yes AFI None
423 E. coli No Yes Yes RTI None
432 E. coli Yes Yes Yes RTI Azithromycin, ceftriaxone Ineffective
440 E. coli Yes Yes Yes UTI Ceftriaxone Ineffective
483 E. coli Yes Yes No AFI Azithromycin, ceftriaxone Ineffective
503 E. coli No No No RTI None
568 E. coli No No No AFI None
639 E. coli Yes No No UTI None
42 K. pneumoniae No No No AFI Ceftriaxone, gentamicin Effective
59 K. pneumoniae No No No RTI Ceftriaxone, metronidazole Effective
64 K. pneumoniae No Yes No Meningitis / encephalitis Ceftriaxone Effective
278 K. pneumoniae Yes Yes Yes SSTI Ceftriaxone, cloxacillin Ineffective
314 K. pneumoniae Yes Yes Yes SSTI Ceftriaxone, vancomycin Ineffective
332 K. pneumoniae Yes Yes Not AFI, sepsis Ceftriaxone, gentamicin Effective
545 K. pneumoniae Yes Yes Yes UTI Tuberculostatic treatment Ineffective
677 K. pneumoniae Yes Not No RTI Ceftazidime, vancomycin Ineffective
681 K. pneumoniae Yes Yes No RTI Ceftriaxone, vancomycin Ineffective
  1. 3GC 3rd generation cephalosporin, UTI urinary tract infection, RTI respiratory tract infection, AFI acute febrile illness (febrile disease with unknown source), SSTI skin and soft tissue infection
  2. *Ineffective, high likelihood of empiric treatment failure based on in vitro AST result