Table 1 The susceptibility and resistance trends of Gram-positive pathogens to antimicrobial agents

S. aureus

MDR

2843

–

–

54.9

–

55.6

–

55.1

–

60.9

–

penicillin G

2667

0.5

16

87.9

12.1

91.2

8.8

88.1

11.9

84.2

15.8

oxacillin

2843

0.5

32

31.3

68.7

39.0

61.0

34.8

65.2

35.9

64.1

amikacin

2843

4

8

3.7

91.6

3.2

86.6

5.1

90.2

4.9

92.1

gentamicin

2360

0.5

32

15.3

84.1

–

–

–

–

17.4

81.7

rifampicin

2843

0.016

0.016

3.0

96.6

5.3

94.1

3.0

95.9

4.1

95.3

ciprofloxacin

2360

0.5

16

21.3

74.6

–

–

–

–

23.9

71.4

levofloxacin

2843

0.25

16

17.9

80.7

21.4

76.5

19.6

78.7

16.2

81.3

moxifloxacin

2843

0.125

4

17.6

78.8

23.5

68.4

20.3

62.8

17.9

78.5

trimethoprim/sulfamethoxazole

2843

0.064

0.25

2.8

97.2

4.8

95.2

7.1

92.9

3.9

96.1

clindamycin

2843

0.25

32

37.0

60.4

29.9

67.4

35.8

61.1

33.1

60.4

erythromycin

2843

32

32

60.1

31.5

64.7

33.7

65.5

28.0

63.3

27.4

daptomycin

2843

0.5

1

0

98.9

0

97.9

0

98.3

0

97.2

linezolid

2843

1

2

0

100

0

100

0

100

0

100

vancomycin

2843

1

2

0

100

0

100

0

100

0

100

teicoplanin

2360

0.5

2

0

100

–

–

–

–

0

100

tetracycline

2843

0.25

32

19.4

77.2

23.5

72.7

24.0

75.7

25.0

70.6

tigecycline

2843

0.125

0.25

1.2

98.8

1.1

98.9

0.7

99.3

4.3

95.7

E. faecium

MDR

950

–

–

92.7

–

85.7

–

81.0

–

91.2

–

penicillin G

950

32

64

88.8

11.2

87.5

12.5

87.3

12.7

86.7

13.3

ampicillin

950

32

32

86.8

13.2

82.1

17.9

88.6

11.4

83.4

16.6

rifampicin

815

8

8

82.2

11.3

–

–

–

–

74.6

15.5

ciprofloxacin

815

16

32

91.9

6.0

–

–

–

–

86.7

8.8

levofloxacin

950

16

32

86.3

8.6

96.4

1.8

77.2

13.9

84.0

11.6

erythromycin

950

32

32

87.9

3.9

83.9

1.8

81.0

6.3

87.8

5.0

daptomycin

950

2

4

0.1

99.9

0

100

1.3

98.7

0

100

linezolid

950

2

2

0.5

93.2

0

100

1.3

98.7

0

100

vancomycin

949

1

2

0.5

97.9

0

100

1.3

98.7

0

100

teicoplanin

815

0.25

1

0.2

99.8

–

–

–

–

0

100

tigecycline

950

0.064

0.5

0.3

87.4

0

98.2

0

96.2

1.1

98.9

E. faecalis

MDR

636

–

–

39.2

–

40.0

–

19.2

–

33.6

–

Penicillin G

636

2

8

9.0

91.0

17.1

82.9

9.6

90.4

9.7

90.3

Ampicillin

636

1

4

7.4

92.6

11.4

88.6

0

100

10.6

89.4

Rifampicin

549

4

8

50.1

23.5

–

–

–

–

52.2

11.5

Ciprofloxacin

549

1

16

25.7

57.2

–

–

–

–

21.2

64.6

Levofloxacin

636

2

16

26.1

64.5

37.1

60.0

44.2

55.8

18.6

76.1

Erythromycin

636

32

32

58.3

13.5

68.6

100

51.9

98.1

61.1

18.6

Daptomycin

636

1

2

0.3

98.4

0

95.3

1.9

98.1

0.9

97.3

Linezolid

636

2

2

1.3

98.7

0

100

3.8

96.2

0.9

99.1

Vancomycin

636

1

2

0

99.4

0

100

0

100

0

100

Teicoplanin

549

0.25

0.25

0.2

99.8

–

–

–

–

0

100

Tigecycline

636

0.125

0.25

0.6

95.4

0

97.1

0

65.4

0

100

S. aureus

MDR

54.2

–

48.3

–

57.9

–

–

0.590

penicillin G

81.2

18.8

91.1

8.9

90.7

9.3

↓

0.004

oxacillin

33.5

66.5

29.9

70.1

25.9

74.1

↓

0.000

amikacin

6.0

84.3

2.4

92.3

2.2

95.7

↓

0.006

gentamicin

19.5

80.5

15.1

84.0

12.4

87.2

↓

0.002

rifampicin

6.0

94.0

1.5

98.2

1.3

98.2

↓

0.000

ciprofloxacin

22.2

72.3

21.9

77.0

19.0

75.9

–

0.031

levofloxacin

20.2

79.3

21.3

76.3

14.4

85.3

↓

0.050

moxifloxacin

20.2

79.3

18.0

78.9

13.7

86.1

↓

0.000

trimethoprim/sulfamethoxazole

1.0

99.0

3.5

96.5

0.9

99.1

↓

0.000

clindamycin

33.7

62.7

29.1

69.4

47.4

52.0

↑

0.000

erythromycin

62.2

22.7

59.4

32.2

55.0

38.2

↓

0.000

daptomycin

0

98.3

0

100

0

100

–

NA

linezolid

0

100

0

100

0

100

–

0.021

vancomycin

0

100

0

100

0

100

–

NA

teicoplanin

0

100

0

100

0

100

–

NA

tetracycline

23.1

73.7

14.0

79.2

15.4

82.9

↓

0.000

tigecycline

1.2

98.8

0.4

99.6

0.1

99.9

↓

0.000

E. faecium

MDR

95.4

–

98.3

–

93.5

–

↑

0.000

penicillin G

90.8

9.2

89.4

10.6

89.5

10.5

–

0.364

ampicillin

90.0

10.0

87.7

12.3

87.4

12.6

–

0.320

rifampicin

77.7

10.8

89.9

8.9

84.0

10.5

↑

0.002

ciprofloxacin

94.6

3.1

97.2

1.7

90.8

8.0

–

0.214

levofloxacin

92.3

4.6

90.5

2.8

83.4

11.7

–

0.553

erythromycin

84.6

6.9

93.3

4.5

88.6

1.5

–

0.044

daptomycin

0

100

0

100

0

100

–

0.139

linezolid

0.8

99.2

1.1

98.9

0.3

99.7

–

0.931

vancomycin

1.5

98.5

0

92.2

0.6

99.1

–

0.935

teicoplanin

0.8

99.2

0

100

0.3

99.7

–

0.807

tigecycline

0

97.7

0

100

0.3

98.5

–

0.710

E. faecalis

MDR

46.7

–

55.6

–

23.5

–

–

0.815

Penicillin G

12.0

88.0

8.3

91.7

6.0

94.0

↑

0.000

Ampicillin

18.5

81.5

2.1

97.9

5.5

94.5

–

0.081

Rifampicin

44.6

29.3

52.8

13.2

49.5

35.0

–

NA

Ciprofloxacin

31.5

46.7

20.8

69.4

29.0

49.0

–

0.126

Levofloxacin

28.3

69.6

24.3

41.0

24.0

75.5

↓

0.000

Erythromycin

56.5

22.8

61.1

4.9

55.5

8.0

↓

0.010

Daptomycin

0

95.7

0

98.6

0

100

–

0.137

Linezolid

0

100

2.8

97.2

0.5

99.5

–

0.710

Vancomycin

0

100

0

97.2

0

100

–

NA

Teicoplanin

1.1

98.9

0

100

0

100

↓

0.019

Tigecycline

3.3

90.2

0

100

0.5

99.5

↑

0.031