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Table 2 Causative pathogens of all nosocomial infection episodes in cancer patients

From: Establishment and validation of a nomogram to predict the in-hospital death risk of nosocomial infections in cancer patients

Causative organisms Whole cohort (n = 1008) Training cohort (n = 708) Validation cohort (n = 300) Pb
Survival (n = 610) Death (n = 98) Pa
Gram-negative bacteria 388 (38.5) 229 (37.5) 31 (31.6) 0.260 128 (42.7) 0.076
 Escherichia coli 135 (13.4) 71 (11.6) 10 (10.2) 0.679 54 (18.0) 0.005*
 Klebsiella pneumoniae 65 (6.4) 38 (6.2) 11 (11.2) 0.071 16 (5.3) 0.348
 Pseudomonas aeruginosa 86 (8.5) 54 (8.9) 4 (4.1) 0.110 28 (9.3) 0.553
 Enterobacter spp. 34 (3.4) 21 (3.4) 2 (2.0) 0.675 11 (3.7) 0.737
 Klebsiella oxytoca 4 (0.4) 3 (0.5) 0 (0.0) 1.000 1 (0.3) 1.000
 Proteus mirabilis 13 (1.3) 8 (1.3) 2 (2.0) 0.915 3 (1.0) 0.822
 Salmonella enterica serovar 2 (0.2) 1 (0.2) 0 (0.0) 1.000 1 (0.3) 0.507
 Haemophilus spp 42 (4.2) 28 (4.6) 2 (2.0) 0.372 12 (4.0) 0.863
 Serratia 7 (0.7) 5 (0.8) 0 (0.0) 1.000 2 (0.7) 1.000
Gram-positive bacteria 143 (14.2) 87 (14.3) 14 (14.3) 0.995 42 (14.0) 0.912
 Staphylococcus aureus 71 (7.0) 40 (6.6) 7 (7.1) 0.829 24 (8.0) 0.440
 MRSA 7 (0.7) 4 (0.7) 2 (2.0) 0.196 1 (0.3) 0.681
 Streptococcus pneumoniae 37 (3.7) 21 (3.4) 3 (3.1) 1.000 13 (4.3) 0.466
 Coagulase-negative staphylococci 15 (1.5) 13 (2.1) 1 (1.0) 0.732 1 (0.3) 0.092
 Streptococcus anginosus 13 (1.3) 9 (1.5) 1 (1.0) 1.000 3 (1.0) 0.822
Enterococcus 26 (2.6) 15 (2.5) 6 (6.1) 0.096 5 (1.7) 0.234
 E. faecalis 12 (1.2) 7 (1.1) 3 (3.1) 0.303 2 (0.7) 0.496
 E. faecium 10 (1.0) 5 (0.8) 2 (2.0) 0.251 3 (1.0) 1.000
 Enterococcus spp 4 (0.4) 3 (0.5) 1 (1.0) 0.450 0 (0.0) 0.324
Anaerobes 6 (0.6) 5 (0.8) 0 (0.0) 1.000 1 (0.3) 0.676
Fungi 115 (11.4) 60 (9.8) 21 (21.4) 0.001 34 (11.3) 0.961
 Candida albicans 79 (7.8) 44 (7.2) 13 (13.3) 0.041* 22 (7.3) 0.698
 Candida spp. 14 (1.4) 7 (1.1) 2 (2.0) 0.805 5 (1.7) 0.844
 Aspergillus flavus 22 (2.2) 9 (1.5) 6 (6.1) 0.010* 7 (2.3) 0.831
MDRGNB 250 (24.8) 162 (26.6) 23 (23.5) 0.518 65 (21.7) 0.134
 ESBL-producing  Escherichia coli 156 (15.5) 102 (16.7) 17 (17.3) 0.878 37 (12.3) 0.073
 MDR Pseudomonas aeruginosa 13 (1.3) 10 (1.6) 0 (0.0) 0.415 3 (1.0) 0.822
 Acinetobacter baumannii 30 (3.0) 18 (3.0) 1 (1.0) 0.447 11 (3.7) 0.401
 Stenotrophomonas maltophilia 16 (1.6) 8 (1.3) 3 (3.1) 0.390 5 (1.7) 1.000
 ESBL-producing Klebsiella pneumoniae 31 (3.1) 20 (3.3) 2 (2.0) 0.732 9 (3.0) 0.928
 Carbapenem-resistant Enterobacteriaceae 4 (0.4) 4 (0.7) 0 (0.0) 1.000 0 (0.0) 0.324
Polymicrobial 80 (7.9) 52 (8.5) 3 (3.1) 0.061 25 (8.3) 0.762
  1. MRSA, Methicillin-resistant S. aureus; MDRGNB, multidrug-resistant gram-negative bacilli; ESBL, extended-spectrum β-lactamase; MDR: multidrug-resistant
  2. aP value for univariate analysis of the training cohort
  3. bP value for clinical characteristics analysis between the training cohort and validation cohort
  4. *Indicates statistical significance