Table 2 Causative pathogens of all nosocomial infection episodes in cancer patients
Causative organisms | Whole cohort (n = 1008) | Training cohort (n = 708) | Validation cohort (n = 300) | Pb | ||
|---|---|---|---|---|---|---|
Survival (n = 610) | Death (n = 98) | Pa | ||||
Gram-negative bacteria | 388 (38.5) | 229 (37.5) | 31 (31.6) | 0.260 | 128 (42.7) | 0.076 |
 Escherichia coli | 135 (13.4) | 71 (11.6) | 10 (10.2) | 0.679 | 54 (18.0) | 0.005* |
 Klebsiella pneumoniae | 65 (6.4) | 38 (6.2) | 11 (11.2) | 0.071 | 16 (5.3) | 0.348 |
 Pseudomonas aeruginosa | 86 (8.5) | 54 (8.9) | 4 (4.1) | 0.110 | 28 (9.3) | 0.553 |
 Enterobacter spp. | 34 (3.4) | 21 (3.4) | 2 (2.0) | 0.675 | 11 (3.7) | 0.737 |
 Klebsiella oxytoca | 4 (0.4) | 3 (0.5) | 0 (0.0) | 1.000 | 1 (0.3) | 1.000 |
 Proteus mirabilis | 13 (1.3) | 8 (1.3) | 2 (2.0) | 0.915 | 3 (1.0) | 0.822 |
 Salmonella enterica serovar | 2 (0.2) | 1 (0.2) | 0 (0.0) | 1.000 | 1 (0.3) | 0.507 |
 Haemophilus spp | 42 (4.2) | 28 (4.6) | 2 (2.0) | 0.372 | 12 (4.0) | 0.863 |
 Serratia | 7 (0.7) | 5 (0.8) | 0 (0.0) | 1.000 | 2 (0.7) | 1.000 |
Gram-positive bacteria | 143 (14.2) | 87 (14.3) | 14 (14.3) | 0.995 | 42 (14.0) | 0.912 |
 Staphylococcus aureus | 71 (7.0) | 40 (6.6) | 7 (7.1) | 0.829 | 24 (8.0) | 0.440 |
 MRSA | 7 (0.7) | 4 (0.7) | 2 (2.0) | 0.196 | 1 (0.3) | 0.681 |
 Streptococcus pneumoniae | 37 (3.7) | 21 (3.4) | 3 (3.1) | 1.000 | 13 (4.3) | 0.466 |
 Coagulase-negative staphylococci | 15 (1.5) | 13 (2.1) | 1 (1.0) | 0.732 | 1 (0.3) | 0.092 |
 Streptococcus anginosus | 13 (1.3) | 9 (1.5) | 1 (1.0) | 1.000 | 3 (1.0) | 0.822 |
Enterococcus | 26 (2.6) | 15 (2.5) | 6 (6.1) | 0.096 | 5 (1.7) | 0.234 |
 E. faecalis | 12 (1.2) | 7 (1.1) | 3 (3.1) | 0.303 | 2 (0.7) | 0.496 |
 E. faecium | 10 (1.0) | 5 (0.8) | 2 (2.0) | 0.251 | 3 (1.0) | 1.000 |
 Enterococcus spp | 4 (0.4) | 3 (0.5) | 1 (1.0) | 0.450 | 0 (0.0) | 0.324 |
Anaerobes | 6 (0.6) | 5 (0.8) | 0 (0.0) | 1.000 | 1 (0.3) | 0.676 |
Fungi | 115 (11.4) | 60 (9.8) | 21 (21.4) | 0.001 | 34 (11.3) | 0.961 |
 Candida albicans | 79 (7.8) | 44 (7.2) | 13 (13.3) | 0.041* | 22 (7.3) | 0.698 |
 Candida spp. | 14 (1.4) | 7 (1.1) | 2 (2.0) | 0.805 | 5 (1.7) | 0.844 |
 Aspergillus flavus | 22 (2.2) | 9 (1.5) | 6 (6.1) | 0.010* | 7 (2.3) | 0.831 |
MDRGNB | 250 (24.8) | 162 (26.6) | 23 (23.5) | 0.518 | 65 (21.7) | 0.134 |
 ESBL-producing  Escherichia coli | 156 (15.5) | 102 (16.7) | 17 (17.3) | 0.878 | 37 (12.3) | 0.073 |
 MDR Pseudomonas aeruginosa | 13 (1.3) | 10 (1.6) | 0 (0.0) | 0.415 | 3 (1.0) | 0.822 |
 Acinetobacter baumannii | 30 (3.0) | 18 (3.0) | 1 (1.0) | 0.447 | 11 (3.7) | 0.401 |
 Stenotrophomonas maltophilia | 16 (1.6) | 8 (1.3) | 3 (3.1) | 0.390 | 5 (1.7) | 1.000 |
 ESBL-producing Klebsiella pneumoniae | 31 (3.1) | 20 (3.3) | 2 (2.0) | 0.732 | 9 (3.0) | 0.928 |
 Carbapenem-resistant Enterobacteriaceae | 4 (0.4) | 4 (0.7) | 0 (0.0) | 1.000 | 0 (0.0) | 0.324 |
Polymicrobial | 80 (7.9) | 52 (8.5) | 3 (3.1) | 0.061 | 25 (8.3) | 0.762 |