Fig. 1

Segmented linear regression of antibiotics consumption during study period in defined daily dose per 1000 patient-days over time. A Aminoglycosides; B Carbapenems; C Class 3 β-lactams (third-generation cephalosporins or ureido/carboxy-penicillins); D Class 4 β-lactams (piperacillin/tazobactam, fourth-generation cephalosporins and antipseudomonal third-generation cephalosporins), E Fluoroquinolones; F Glycopeptides. Solid lines represent the crude 2-months antibiotic consumption. The dashed lines represent the linear regression for each period