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Table 2 Proportion of COVID-19 patients with resistant co-infections

From: Antimicrobial resistance (AMR) in COVID-19 patients: a systematic review and meta-analysis (November 2019–June 2021)

First author

Disease presentation

Patients screened (No.)

SARS-CoV-2 patients (No.)

Number of patients with co-infections (%)*

Number of patients with resistant co-infections (%)*

Chowdhary [31]

BSI

596

596

15 (2.5%)

10 (1.7%)

Bogossian [44]

COVID-19

75

69

24 (34%)

23 (33%)

Ramadan [33]

COVID-19

260

260

28 (11%)

28 (11%)

Amarsy [45]

BSI, Respiratory Distress

96

95

4 (45%)

4 (4%)

Perez [19]

VAP, VAP with bacteremia, bacteremia, bone or soft tissue infections

34

17

17 (100%)

17 (100%)

Salehi [22]

OPC

1059

1059

53 (5.0%)

2 (0.2%)

Cataldo [46]

BSI

57

57

28 (49%)

9 (16%)

Posteraro [47]

79 M with complicated T2DM who had fever, necrotic and ulcerative lesions on the amputated leg stump, BSI

1

1

1 (100%)

1 (100%)

Nori [3]

COVID-19 and subsequent positive microbiological results (within 30 days)

4267

4267

152 (3.6%)

25 (0.6%) †

Mahmoudi [48]

COVID-19 patients assessed for bacterial infections

340

340

43 (13%)

31 (72%)

Li [49]

Lung, BSI and UTI

1495

1495

102 (6.8%)

102 (6.8%)‡

Contou [18]

All microbiological investigations performed within the first 48 h of ICU admission were reviewed

92

92

26 (28%)

7 (8%)§

Mo [22]

COVID-19 patients who received Tocilizumab

617

38

15 (39%)

11 (29%)

Garcia-Menino [8]

Suspected or confirmed COVID-19 Patients

62

62

7 (11%)

7 (11%)

Sharifipour [20]

COVID-19 Patients

19

19

19 (100%)

17 (89%)

Walpole [50]

33 M with fever for 3 days, abdominal pain for 1 day and one episode of vomiting

1

1

1 (100%)

1 (100%)

Razazi [10]

Viral ARDS

3821

90

NA

21 (23%)

Guisado-Gil [17]

Hospital-acquired Candidemia and MDR BSI

282

282

NA¶

NA¶

Montrucchio [51]

COVID patients screened for carbapenemase-producing K. pneumoniae

35

7

6 (86%)

6 (86%)

Mady [23]

COVID-19 patients with ARDS receiving tocilizumab

61

61

12 (20%)

3 (5%)

Tiri [52]

Patients admitted to ICU screened using rectal swabs or clinical cultures for CRE

62

62

17 (27%)

17 (27%)

Perrotta [54]

57 M admitted to hematology with K. pneumoniae NDM sepsis

1

1

1 (100%)

1 (100%)

Baiou [55]

Critical COVID-19 Patients

1231

234

78 (6%)

NA

Segrelles-Calvo [56]

Adult patients admitted to ICU or RICU

215

215

7 (3%)

NA

Martinez-Guerra [57]

Severe COVID-19 patients

794

794

74 (11%)

127 (20%)††

Karruli [58]

Critically Ill COVID-19 Patients

32

32

NA/32

16 (50%)

Gomez-Simmonds [60]

Secondary CPE infections in COVID-19 patients

3152

3152

NA

13 (0.4%)

Cultrera [61]

COVID-19 patients admitted in ICU and non-COVID-19 ICU settings

NA

NA

28

NA

Khurana [62]

Severely ill COVID-19 patients

1179

1179

151 (13%)

105 (9%)

Posteraro [70]

BSI in COVID-19 patients

293

293

46 (16%)

12 (5%)

Pascale [63]

 > 18 years admitted to ICU

1151

1151

NA/1151

23 (1.8%)

Baskaran [64]

COVID-19 patients in ICU

579

254

83 (33%)

NA/254

Moretti [65]

Patients with COVID-19 and VAP

39

39

21 (54%)

67%#

Grasselli [66]

Patients with COVID-19 pneumonia

813

813

359 (44%)

38%**

Magnasco [67]

Patients with severe COVID-19

118

118

NA/118

14 (12%)

Bentivegna [68]

Patients in COVID-19 Departments

NA

NA

NA/NA

150/NA

Suarez-de-la-Rica [69]

Mechanically ventilated critically ill COVID-19 patients

107

107

46 (43%)

17 (16%)

Kokkoris [42]

BSI in COVID-19 patients

50

50

27 (54%)

17 (34%)‡‡

TOTAL

 

23,086

16,602

  
  1. Abbreviations: BSI (blood stream infection), VAP (ventilator-associated pneumonia), OPC (oropharyngeal candidiasis), MDR (multi-drug resistant), T2DM (type II diabetes mellitus), UTI (urinary tract infection), ARDS (acute respiratory distress syndrome), CRE (carbapenem-resistant Enterobacteriaceae), RICU (Respiratory Intermediate Care Unit)
  2. *Denominator: Patients with SARS-CoV-2
  3. 24 organisms resistant; no patient level data provided
  4. 159 organisms detected; no patient level data provided; however, all resistant
  5. §7 organisms resistant to 3rd generation cephalosporins and amoxicillin-clavulanate, no patient level data
  6. Rates of MDR BSIs
  7. #67% of 27 organisms isolated were MDR, 1 was XDR
  8. **272/723 microbiologically confirmed hospital acquired infections were MDR
  9. ††19.3% (127/656) episodes of hospital-acquired infections demonstrated resistance
  10. ‡‡34% (17/50) were reported as extensively drug-resistant, pan-drug resistant or resistant