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Table 2 Other potential resistance conferring mutations in the genes implicated in Bedaquiline, Clofazimine, Linezolid and Delamanid resistance

From: First report of whole-genome analysis of an extensively drug-resistant Mycobacterium tuberculosis clinical isolate with bedaquiline, linezolid and clofazimine resistance from Uganda

Drug

Gene

Other potential resistance conferring mutations

Mutation type

Bedaquilin and Clofazimine

mmpL5

p.Ile948Val, p.Gly131Arg, p.Thr352Pro

Missense variants

Rv0678

p.Ala124Gly, p.Asp141Glu, p.Thr161Asn,

Missense variants

Rv1979c

p.Ala128Ser, p.Pro349Ala

Missense variants

pepQ

p.Ala224Ser, p.Leu300Arg, p.Leu362Trp,

Missense variants

Linezolid

rplC

p.Gly153Glu p.Ala155Asp, p.Thr156Pro

Missense variant

Delamanid

fgd1

p.Ser38Arg, p.Thr92Pro, p.Phe102Cys, p.Gly199Ala, p.Glu213Asp

Missense variants

fbiC

p.Cys59Gly, p.Asp375Ala, p.Glu376Gly, p.Trp405Gly, p.Ile406Ser, p.Asp492Tyr, p.Glu503Gly, p.Ile638Ser, p.Leu672Val,p.Leu672Arg, p.Asp673Ala, p.Pro686Ala, p.Glu692Ala,

Missense variants

p.Glu152*

Nonsense mutation

fbiA

p.Val73Gly, p.Met319Arg

Missense variants

fbiB

p.Ile18Val, p.Ser54Ala, p.Ala104Glu, p.Leu249Arg, p.Glu250Ala, p.Ser262Ala, p.Val263Gly,

Missense variants

ddn

p.Glu35Lys, p.Glu35Gly, p.Asp108Glu

Missense variants

Rv2983

p.His159Pro

Missense variant