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Table 3 Multivariate analysis of factors associated with the detection of class I and class III pathogens

From: Impact of early antibiotic exposure on the risk of colonization with potential pathogens in very preterm infants: a retrospective cohort analysis

 

GA < 32 (n = 1407, 100%)

GA < 28 (n = 480, 34.1%)*

Class I pathogens

Class III pathogens

Class I pathogens

 

Class III pathogens

 

(a)OR (95% CI)

p value

(a)OR (95% CI)

p value

(a)OR (95% CI)

p value

(a)OR (95% CI)

p value

Gestational age (weeks)

0.9 (0.8–1.0)

0.13

n.a

n.a

0.9 (0.7–1.1)

0.15

n.a

n.a

Birth weight (g)

1.0 (1.0–1.0)

0.61

n.a

n.a

n.a

n.a

n.a

n.a

Admitting hospital

        

 I

1

 

1

 

1

   

 II

1.4 (1.0–2.0)

0.08

2.1 (1.5–2.7)

< 0.01

1.8 (1.0–3.3)

0.05

n.a

n.a

 III

0.1 (0.0–0.2)

 < 0.01

1.5 (1.2–2.0)

0.01

0.1 (0.0–0.3)

< 0.01

  

Prenatal ABX

1.2 (0.8–1.7)

0.47

n.a

n.a

1.3 (0.7–2.3)

0.53

n.a

n.a

pPROM

1.2 (0.8–1.9)

0.33

n.a

n.a

1.4 (0.8–2.5)

0.21

n.a

n.a

Mode of delivery

        

 Spontaneous

1

   

1

 

1

 

 Elective C/S

1.0 (0.5–1.8)

0.89

n.a

n.a

0.7 (0.3–1.7)

0.43

1.2 (0.6–2.3)

0.58

 Emergency C/S

1.2 (0.7–2.1)

0.56

  

0.9 (0.4–1.9)

0.73

1.8 (0.9–3.5)

0.09

  1. Significant p-values are printed in bold
  2. GA gestational age; ABX antibiotics; pPROM premature preterm rupture of membranes; C/S caesarean section; FIP focal intestinal perforation. Corresponding umbers and p values from univariate analysis are shown in Additional file 2: Table S1. *subgroup analysis