Table 2 Patient characteristics on intensive care unit admission according to the empirical antimicrobial treatment strategy used
Total | Broad-spectrum antimicrobial group | Narrow-spectrum antimicrobial group | p value | |
|---|---|---|---|---|
n = 254 | n = 159 | n = 95 | ||
Age | 72 (59–80.25) | 73 (62–80) | 72 (53–82) | 0.401 |
Sex | 0.698 | |||
Male | 143 (56.3%) | 88 (55.3%) | 55 (57.9%) | |
Female | 111 (43.7%) | 71 (44.7%) | 40 (42.1%) | |
Severity on ICU admission | ||||
APACHE II on ICU admission | 20 (15–26) | 21 (17–27) | 17 (13–26) | 0.002 |
SAPS II on ICU admission | 43 (29–57) | 48 (34–61) | 37 (22–50) | < 0.001 |
Total SOFA score on ICU admission | 7 (5–10) | 8 (5–11) | 5 (4–9) | < 0.001 |
Admission category | ||||
Medical | 175 (68.9%) | 109 (68.6%) | 66 (69.5%) | > 0.999 |
Surgical | 74 (29.1%) | 47 (29.6%) | 27 (28.4%) | 0.887 |
Trauma | 5 (2.0%) | 3 (1.9%) | 2 (2.1%) | > 0.999 |
Admission diagnosisa | ||||
Respiratory | 80 (31.5%) | 46 (28.9%) | 34 (35.8%) | 0.267 |
Digestive | 68 (26.8%) | 53 (33.3%) | 15 (15.8%) | 0.002 |
Cardiovascular | 62 (24.4%) | 36 (22.6%) | 26 (27.4%) | 0.451 |
Neurological | 36 (14.2%) | 17 (10.7%) | 19 (20.0%) | 0.043 |
Renal genitourinary | 30 (11.8%) | 17 (10.7%) | 13 (13.7%) | 0.548 |
Trauma skin | 21 (8.3%) | 12 (7.5%) | 9 (9.5%) | 0.641 |
Other | 26 (10.2%) | 16 (10.1%) | 10 (10.5%) | > 0.999 |
Comorbidities (N = 241) | ||||
Cardiovascular | 58 (24.1%) | 38 (25.0%) | 20 (22.5%) | 0.755 |
Diabetes mellitus | 54 (22.4%) | 35 (23.0%) | 19 (21.3%) | 0.873 |
Solid tumor | 40 (16.6%) | 28 (18.4%) | 12 (13.5%) | 0.372 |
Renal failure | 31 (12.9%) | 22 (14.5%) | 9 (10.1%) | 0.426 |
Cerebrovascular | 31 (12.9%) | 24 (15.8%) | 7 (7.9%) | 0.109 |
Pulmonary | 26 (10.8%) | 18 (11.8%) | 8 (9.0%) | 0.528 |
Other | 18 (7.5%) | 15 (9.9%) | 3 (3.4%) | 0.077 |