Table 1 Input parameters and plausible ranges for sensitivity analysis

N_p

No. of beds

25

5–50

[13]

N_h

Number of HCWs

10

[14, 15]

c_p

Number of HCW visits associated with at least one aseptic contact per patient per day

28

21–39

[13, 14]

a

No. of HCW visits associated with at least one aseptic contact per HCW per day

2.8

c_p/N_h

Mean length of stay (days)

d_S

-Uncolonised

6.2

3.5–8

[47]

d_CNId

-Colonised non-identified

12

1–50

[21]

d_I

-Infected/colonised identified

25

4–150

[27, 29, 39, 48,49,50]

γ_S

Discharge rate of uncolonised patients (per day)

0.16

1/d_S

γ_CNId

Discharge rate of colonised non-identified patients (per day)

0.08

1/ d_CNId

γ_I

Discharge rate of infected patients (per day)

0.04

1/ d_I

b_p

Colonisation probability for patients (/ contact)

0.021

0.009–0.021

Model’s calibration based on the literature[21, 22]

b_h

Probability of contamination of an HCW with CPE during a contact with a colonised patient (/contact)

0.21

0.05–0.4

[7, 51,52,53]

μ₀

Natural decontamination rate for HCW (i.e. not by hand hygiene) (/day)

24

12–48

[7, 54]

p_inf

Probability of infection in colonised patient

0.0757

0.0541–0.1024

[9, 30, 39, 35, 55]

Probability of death during hospital stay

pd_S

-Uncolonised

0.020

0.012–0.036

[31]

pd_C

-Colonised

0.036

0.018–0.054

[32]

pd_I

-Infected

0.30

0.09–0.9

[9, 33, 39, 49, 56,57,58]

p_p

Probability of hand hygiene before contact with patient (uncolonised or colonised unidentified)

0.4

0.06–0.9

[34]

p_h

Probability of hand hygiene after contact with patient (uncolonised or colonised unidentified)

0.51

0.06–0.9

[34]

φ

Prevalence of CPE carriage among admitted patients

0.001

0.001–0.05

[17,18,19,20]

α

Colonisation rate by hospital environment (/day)

0.00001

0.00001–0.00041

[23,24,25]

Control mesures’ specific parameters

r_a

Part of colonised patients, identified at admission in a risk-based screening

0.5

0.2–0.5

Local data and [17, 35]

s_b

Sensitivity of the screening method (%)

0.96

0.9–1

[59,60,61]

s_p

Specificity of the screening method (%)

1

Assumed

p_id

Probability of hand hygiene before/after contact with identified CPE patient

0.8

[36, 62]

r_s

Part of single room in the ward (%)

10

Assumed