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Table 5 Antibiotic resistance pattern in K. pneumoniae based on seasons

From: Assessment of antibiotic resistance changes during the Covid-19 pandemic in northeast of Iran during 2020–2022: an epidemiological study

Antibiotic

Season

Winter 2020

Spring 2020

Summer 2020

Fall 2020

Winter 2021

Spring 2021

Summer 2021

Fall 2021

Winter 2022

P value

AP

2 (66.6)

7 (100)

15 (100)

13 (92.8)

28 (100)

22 (100)

6 (100)

3 (100)

5 (100)

 < 0.001

CZ

1 (50)

11 (78.5)

15 (68.1)

10 (58.2)

24 (80)

25 (86.2)

41 (93.1)

23 (82.1)

11 (78.5)

 < 0.001

GM

12 (63.1)

7 (41.1)

9 (34.6)

16 (51.6)

23 (47.9)

11(31.4)

5 (13.5)

14 (33.3)

1 (100)

 < 0.001

AK

3 (75)

2 (28.5)

9 (56.2)

13 (68.4)

3 (75)

10 (25)

4 (57.1)

6 (54.5)

 < 0.001

SAM

2 (33.3)

11 (91.6)

12 (100)

24 (82.7)

22 (84.6)

21 (65.6)

24 (88.8)

16 (84.2)

 < 0.001

PTZ

3 (75)

4 (57.1)

12 (75)

13 (68.4)

23 (79.3)

3 (100)

0 (0)

18 (75)

5 (62.5)

 < 0.001

CPM

2 (100)

6 (75)

12 (75)

14 (82.3)

25 (92.5)

20 (86.9)

25 (89.2)

17 (89.4)

1 (100)

 < 0.001

FOX

2 (100)

4 (57.1)

10 (83.3)

10 (66.6)

21 (77.7)

11 (61.1)

0 (0)

2 (100)

20 (68.9)

 < 0.001

CTX

6 (85.7)

1 (50)

3 (100)

2 (100)

0 (0)

1 (50)

0.001

CRO

22 (84.6)

12 (75)

16 (61.5)

22 (64.7)

40 (83.3)

39 (82.9)

43 (91.4)

31 (77.5)

30 (76.9)

0.070

CIP

5 (71.4)

2 (100)

0 (0)

4 (80)

1 (100)

0.007

LEV

2 (100)

3 (100)

2 (100)

1 (100)

4 (80)

1 (100)

0.219

IMI

7 (38.8)

3 (20)

17 (65.3)

23 (69.6)

37 (75.5)

31 (81.5)

36 (83.7)

30 (83.3)

29 (74.3)

 < 0.001

MEM

11 (55)

5 (31.2)

13 (48.1)

18 (54.5)

45 (91.8)

39 (84.7)

22 (66.6)

32 (69.5)

12 (85.7)

 < 0.001

CAZ

6 (100)

8 (88.8)

13 (86.6)

12 (100)

1 (100)

1 (100)

2 (100)

8 (100)

22 (88)

 < 0.001

NI

3 (9.3)

12 (46.1)

20 (54)

15 (25.4)

7 (8.4)

8 (11.1)

19 (28.7)

11 (14.8)

1 (3.7)

0.472

  1. AP (Ampicillin), CZ (Cefazolin), GM (Gentamicin), AK (Amikacin), SAM (Ampicillin-Sulbactam), PTZ (Pipracillin-Tazobactam), CPM (Cefepime), FOX (Cefoxitin), CTX (Cefotaxime), CRO (Ceftriaxone), CIP (Ciprofloxacin), IMI (Imipenem), MEM (Meropenem), CAZ (Ceftazidim) and NI (Nitrofurantoin).
  2. Variables were described as the frequency (%).
  3. *Samples for which antibiotic resistance testing has not been performed are marked with "–".