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Table 1 Definitions of appropriate, inappropriate, and suboptimal antibiotic treatment

From: Impact of suboptimal or inappropriate treatment on healthcare resource use and cost among patients with uncomplicated urinary tract infection: an analysis of integrated delivery network electronic health records

Appropriate treatment

Inappropriate treatment

Suboptimal treatment

Patients were prescribed first-line therapy which consists of fosfomycin, nitrofurantoin, or SXT, alone OR

Patients with known allergies were prescribed appropriate subsequent line of treatments AND

Prescription durations were appropriate to the treatment such as:

5 days for nitrofurantoin

1 day for fosfomycin

3 days for SXT

Patients were prescribed two first-line therapies OR

Patients received β lactam agents, fluoroquinolones, or any other second-line or alternate therapy as initial therapy if patients were not allergic or resistant to first-line therapies OR

Patients received antibiotics which they showed resistance to OR

Patients received antibiotics that they were allergic to, identified by the patient history and drug allergy tables

Patients had to switch from current therapy to another first-line, second-line, or third-line therapy OR

Patients received intravenous antibiotics (oral administration is the appropriate route for patients with uUTI)

  1. SXT trimethoprim-sulfamethoxazole, uUTI uncomplicated urinary tract infection