Table 1 Definitions of contacts and interventions used
Contacts | Contact definition | Investigation period | Diagnostic and therapeutic interventions |
|---|---|---|---|
Infants | Every neonate admitted to NICU for > 24 h during the same period as the index patient’s infant | Entire period during admission of the index patient’s infant, regardless the time period to the diagnosis | TST and T-Spot at baseline, TST after 6 months of exposure No prophylactic treatment, as exposure was at least 6 weeks ago at time of investigation |
Relatives of contact infants | Every relative of a neonate admitted for > 4 days at the NICU during the same period as the index patient’s infant | Until 3 months before diagnosis and initiation of therapy of the index patient | TST or Quantiferon 8 weeks after last exposure, CXR in case of positive result Isoniazid or rifampicin in case of newly diagnosed latent TB |
Family members | Every family member | Na | Adults: TST or Quantiferon 8Â weeks after last exposure, CXR in case of positive result Isoniazid or rifampicin in case of newly diagnosed latent TB Children: TST(& IGRA in the newborn), chest X-ray and gastric lavage at baseline and TST 8Â weeks after last exposure; Isoniazid up to second negative TST |
Other patients | Every patient sharing the same room as the index patient for more than 8Â h during the index patients instays | Until 3Â months before diagnosis and initiation of therapy of the index patient | TST or Quantiferon 8Â weeks after last exposure, CXR in case of positive result Isoniazid or rifampicin in case of newly diagnosed latent TB |
Health care workers | Close nursing contact to the index patient or cumulative contact for more than 8 h to the index patient’s infant or herself | Entire period during admission of the index patient’s infant, and during her own instays, regardless the time period to the diagnosis | TST or Quantiferon 8 weeks after last exposure, CXR in case of positive result Isoniazid or rifampicin in case of newly diagnosed latent TB |