Skip to main content

Table 2 Summary of reviewed literature

From: Low secondary attack rate after prolonged exposure to sputum smear positive miliary tuberculosis in a neonatal unit

References

Year

Country

Index patient

Investigation

Intervention

Results infants

Results other primary contacts

Results HCW

1

 > 1

Infants

Adults

Pos. TST 1°

Pos. TST 2°

Pos. TST 2°

Conversion

Pos. TST 2°

Conversion

Lee et al. [22]

1997

USA (NYC)

infant with congenital TB; mother described as healthy

 

TST, gastric aspirate, CXR if already discharged

TST, CXR if TST positive

Isoniazid, Pyridoxine for 6 months

0/14

0/10

4/27

unknown

2/260

2/260

Grisaru-S. et al. [20]

2014

Israel

infant with congenital TB; mother with pulmonary TB

 

TST, CXR if TST positive

TST, CXR if TST positive

INR if < 3 months old or > 3 months and immunodeficient

0/97

1/75

32/156

11/80

48/115

3/41

Crockett et al. [11]

2004

Canada

 

2 infants with congenital TB *

TST, CXR, CT if abnormal CXR, gastric aspirate

TST, CXR

INH until TST negative, evaluation after 1 and 3 months

na

na

3/3

2/3

na

3/328

Isaacs et al. [19]

2006

Australia

mother with pulmonary TB

 

TST, CXR, gastric aspirate if abnormal CXR

TST, CXR

INH for 6 months, treatment of TB disease in high suspicion

0/13

na

2/20

2/20

0/40

0/40

Laartz et al. [23]

2002

USA (Florida)

Infant with congenital TB; mother with endometrial biopsy culture positive

 

TST, CXR if TST positive

na

INH for 3 to 6 months

0/36

0/30

1/106

1/106

0/120

0/120

Winters et al. [2]

2010

USA (NYC)

Infant congenital TB; mother sputum negative

 

TST, CXR

TST, CXR if TST positive

na

na

0/13

na

0/10

2/64

2/64

Ahn et al. [15]

2015

Korea

nurse, pulmonary TB

 

TST, CXR

TST, CXR

INH for 3 months

2/108

2/106

na

na

33/59

6/59

Fisher et al. [14]

2014

Australia

medical officer with smear positive pulmonary TB

 

TST (month 3 of age), CXR

TST, CXR

INH until negative TST

0/125

0/89

51/152

3/152

9/120

1/120

Nania et al. [16]

2007

USA (Nashville)

respiratory therapist

 

None

TST

none

na

na

0.5

0/5

0/223

0/223

Perry et al. [17]

2012

France (Paris)

caregiver, pulmonary TB (culture positive)

 

TST (month 0 and 3), CXR

na

INH and Rifampicin for 3 months

4/172

1/150

na

na

na

na

Mouchet et al. [12]

2004

Belgium (Brussels)

infant with congenital TB; mother: chest X-Ray negative

 

TST, gastric aspriate in some children, CXR

HCW: TST or CXR family members: CXR

INH to high risk infants

0/85

na

na

na

na

6/32

Steiner et al. [18]

1975

USA (NYC)

nurse aid, cavitary disease, sputum/culture negative, asymptomatic

 

TST, CXR if TST positive

TST, CXR in case of positive TST

none

2/1647; 2 with active disease

na

18/18

na

na

Na

Saitoh et al. [13]

2001

Japan

infant with congenital TB; mother with menstrual discharge positive

 

TST, CXR

TST, CXR

INH for 3 months only to the children at NICU

0/99

0/99

na

na

3/144

3/144

Lee et al. [21]

2004

USA (NYC)

infant with congenital TB

 

TST, CXR

TST, CXR in case of positive TST

INR for 3 months

0/11

1/15

na

na

4/211

4/211

  1. *Child to child transmission via contaminated resp. equipment