References | Year | Country | Index patient | Investigation | Intervention | Results infants | Results other primary contacts | Results HCW | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 |  > 1 | Infants | Adults | Pos. TST 1° | Pos. TST 2° | Pos. TST 2° | Conversion | Pos. TST 2° | Conversion | ||||
Lee et al. [22] | 1997 | USA (NYC) | infant with congenital TB; mother described as healthy | Â | TST, gastric aspirate, CXR if already discharged | TST, CXR if TST positive | Isoniazid, Pyridoxine for 6Â months | 0/14 | 0/10 | 4/27 | unknown | 2/260 | 2/260 |
Grisaru-S. et al. [20] | 2014 | Israel | infant with congenital TB; mother with pulmonary TB |  | TST, CXR if TST positive | TST, CXR if TST positive | INR if < 3 months old or > 3 months and immunodeficient | 0/97 | 1/75 | 32/156 | 11/80 | 48/115 | 3/41 |
Crockett et al. [11] | 2004 | Canada | Â | 2 infants with congenital TB * | TST, CXR, CT if abnormal CXR, gastric aspirate | TST, CXR | INH until TST negative, evaluation after 1 and 3Â months | na | na | 3/3 | 2/3 | na | 3/328 |
Isaacs et al. [19] | 2006 | Australia | mother with pulmonary TB | Â | TST, CXR, gastric aspirate if abnormal CXR | TST, CXR | INH for 6Â months, treatment of TB disease in high suspicion | 0/13 | na | 2/20 | 2/20 | 0/40 | 0/40 |
Laartz et al. [23] | 2002 | USA (Florida) | Infant with congenital TB; mother with endometrial biopsy culture positive | Â | TST, CXR if TST positive | na | INH for 3 to 6Â months | 0/36 | 0/30 | 1/106 | 1/106 | 0/120 | 0/120 |
Winters et al. [2] | 2010 | USA (NYC) | Infant congenital TB; mother sputum negative | Â | TST, CXR | TST, CXR if TST positive | na | na | 0/13 | na | 0/10 | 2/64 | 2/64 |
Ahn et al. [15] | 2015 | Korea | nurse, pulmonary TB | Â | TST, CXR | TST, CXR | INH for 3Â months | 2/108 | 2/106 | na | na | 33/59 | 6/59 |
Fisher et al. [14] | 2014 | Australia | medical officer with smear positive pulmonary TB | Â | TST (month 3 of age), CXR | TST, CXR | INH until negative TST | 0/125 | 0/89 | 51/152 | 3/152 | 9/120 | 1/120 |
Nania et al. [16] | 2007 | USA (Nashville) | respiratory therapist | Â | None | TST | none | na | na | 0.5 | 0/5 | 0/223 | 0/223 |
Perry et al. [17] | 2012 | France (Paris) | caregiver, pulmonary TB (culture positive) | Â | TST (month 0 and 3), CXR | na | INH and Rifampicin for 3Â months | 4/172 | 1/150 | na | na | na | na |
Mouchet et al. [12] | 2004 | Belgium (Brussels) | infant with congenital TB; mother: chest X-Ray negative | Â | TST, gastric aspriate in some children, CXR | HCW: TST or CXR family members: CXR | INH to high risk infants | 0/85 | na | na | na | na | 6/32 |
Steiner et al. [18] | 1975 | USA (NYC) | nurse aid, cavitary disease, sputum/culture negative, asymptomatic | Â | TST, CXR if TST positive | TST, CXR in case of positive TST | none | 2/1647; 2 with active disease | na | 18/18 | na | na | Na |
Saitoh et al. [13] | 2001 | Japan | infant with congenital TB; mother with menstrual discharge positive | Â | TST, CXR | TST, CXR | INH for 3Â months only to the children at NICU | 0/99 | 0/99 | na | na | 3/144 | 3/144 |
Lee et al. [21] | 2004 | USA (NYC) | infant with congenital TB | Â | TST, CXR | TST, CXR in case of positive TST | INR for 3Â months | 0/11 | 1/15 | na | na | 4/211 | 4/211 |