Table 1 Baseline characteristics of asymptomatic CRE carriers in children with hematologic disease
Factors | CRE-carriers who did not developed BSI (n = 40) | CRE-carriers who developed BSI (n = 19) | P value |
|---|---|---|---|
Male, no. (%) | 23 (57.5) | 8 (42.1) | 0.269 |
Age (years), median (range) | 3 (1–13) | 8 (1–13) | 0.089 |
CRE strains, no. (%) | Â | Â | Â |
 Escherichia coli | 22 (55.0) | 13 (68.4) | 0.561 |
 Klebsiella pheuminiae | 7 (17.5) | 3 (15.8) | |
 Enterobacter cloacae | 11 (27.5) | 3 (15.8) | |
Prior antibiotic exposure, no. (%) | Â | Â | Â |
  Cephalosporin | 27 (67.5) | 15 (78.9) | 0.364 |
 Carbapenem | 8 (20.0) | 9 (43.4) | 0.030 |
  Glycopeptides | 5 (12.5) | 7 (36.8) | 0.030 |
  Fluoroquinolone | 3 (7.5) | 2 (10.5) | 0.697 |
Underlying diagnosis | Â | Â | Â |
 Acute leukemia | 28 (70.0) | 14 (73.7) | 0.770 |
 Severe aplastic anemia | 12 (30.0) | 5 (26.3) | |
Mucosal damage, no. (%) | 18 (45.0) | 16 (84.2) | 0.004 |
 Oral mucositis | 5 (12.5) | 4 (21.0) | 0.393 |
  Gastroenteritis | 13 (32.5) | 12 (63.2) | 0.026 |
Combined antibiotic therapy, no. (%) | 9 (22.5) | 10 (52.6) | 0.021 |
Repeated admission, no. (%) | 27 (67.5) | 13 (68.4) | 0.944 |
Central venous catheter, no. (%) | 21 (52.5) | 11 (57.9) | 0.698 |
Admission to ICU within 60-day, no. (%) | 13 (32.5) | 16 (84.2) | < 0.001 |
Neutropenia duration ≥ 7 days, no. (%) | 22 (55.0) | 18 (94.7) | 0.002 |
Status of acute leukemia | Â | Â | Â |
 Completed remission, no. (%) | 20 (50.0) | 8 (42.1) | 0.355 |
 Relapse, no. (%) | 4 (14.3) | 5 (35.7) | 0.111 |