Table 2 Individual and pooled parameters used in the meta-regression

Hospital-acquired (HA) bloodstream infection (BSI) with IVC

Hospital-acquired BSI was defined as a BSI detected ≥ 48 h after hospital admission and the patient had an intravascular catheter in situ

A

True BSI for common skin commensal

True BSI for common skin commensal (CSC) was defined as at least two positive blood cultures within 3 to 7 days according to studies included. CSC included diphtheroid, Bacillus species, Cutibacterium species, coagulase-negative staphylococci, and micrococci

B

Clinical data

Clinical data (e.g., fever defined by temperature > 38.0 °C, hypotension defined by systolic pressure < 90 mmHg) were considered in the algorithm

C

Administration of antibiotics

Administration of antibiotics was considered in the algorithm

D

New episode

The same microorganism isolated in a separate blood culture was considered as a new episode only if identified after at least between 3 and 7 days after the first episode, according to studies

E

Cultures from any other sites

A bloodstream infection was not considered catheter related or associated if the same pathogen was identified from a culture in any other body sites

F

Cultures from specific other sites

A bloodstream infection was not considered catheter related or associated if the same pathogen was identified in cultures from one of the following body sites: respiratory track, urinary or wound

G

HA BSI with IVC + true BSI for common skin commensal + clinical data

Cf. definitions above

H

HA BSI with IVC + true BSI for common skin commensal + administration of antibiotics

Cf. definitions above

I

HA BSI with IVC + true BSI for common skin commensal + new episode

Cf. definitions above

J

HA BSI with IVC + true BSI for common skin commensal + culture from any other sites

Cf. definitions above

K

HA BSI with IVC + true BSI for common skin commensal + culture from specific another sites

Cf. definitions above

L

HA BSI with IVC + true BSI for common skin commensal + new episode + culture from any other sites

Cf. definitions above

M

HA BSI with IVC + true BSI for common skin commensal + new episode + culture from specific another sites

Cf. definitions above

N

HA BSI with IVC + true BSI for common skin commensal + clinical data + culture from any other sites

Cf. definitions above

O

HA BSI with IVC + true BSI for common skin commensal + clinical data + culture from specific another sites

Cf. definitions above

P