Table 1 Results of logistic regression regarding risk of having at least one positive household contact
From: SARS-CoV-2 risk in household contacts of healthcare workers: a prospective cohort study
Univariable analysis N = 2406 | Multivariable analysis (model 1), N = 2308 | Multivariable analysis (model 2*), N = 2308 | Multivariable analysis (model 3*), N = 1681 | |||||
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |
HCW characteristics | ||||||||
Age (years), median (interquartile range) | 0.99 (0.98–1.00) | 0.02 | 0.99 (0.98–1.00) | 0.06 | 0.99 (0.98–1.00) | 0.20 | 0.99 (0.98–1.01) | 0.45 |
Body mass index, median (range) | 1.00 (0.97–1.02) | 0.79 | 1.00 (0.98–1.03) | 0.84 | 1.00 (0.98–1.03) | 0.79 | 0.99 (0.96–1.03) | 0.73 |
Male gender | 1.05 (0.83–1.34) | 0.68 | 1.16 (0.87–1.55) | 0.33 | 1.26 (0.91–1.74) | 0.17 | 1.25 (0.88–1.78) | 0.22 |
Active smoker (vs. never/former) | 0.75 (0.54–1.04) | 0.09 | 0.77 (0.55–1.08) | 0.13 | 0.93 (0.64–1.36) | 0.72 | 0.86 (0.57–1.29) | 0.46 |
At least one comorbidity | 1.08 (0.88–1.32) | 0.47 | 1.20 (0.97–1.49) | 0.09 | 1.22 (0.96–1.55) | 0.10 | 1.38 (1.06–1.79) | 0.02 |
HCW related factors | ||||||||
Cumulative patient contact in hours (OR per category) | 1.07 (1.03–1.11) | < 0.001 | 1.08 (1.04–1.12) | < 0.001 | 0.96 (0.91–1.01) | 0.08 | 1.11 (1.05–1.17) | < 0.001 |
Always respirator (vs. surgical/mixed mask use) | 0.62 (0.47–0.82) | < 0.001 | 0.65 (0.49–0.86) | 0.003 | 0.88 (0.64–1.21) | 0.44 | 0.78 (0.55–1.10) | 0.15 |
Working ≥ 80% FTE | 0.88 (0.72–1.07) | 0.20 | 0.91 (0.70–1.19) | 0.51 | 0.83 (0.61–1.13) | 0.23 | 0.80 (0.57–1.11) | 0.17 |
Working in intensive care | 1.10 (0.77–1.57) | 0.59 | 1.09 (0.74–1.61) | 0.66 | 1.32 (0.86–2.04) | 0.20 | 1.13 (0.72–1.77) | 0.60 |
SARS-CoV-2 vaccination | 0.56 (0.43–0.72) | < 0.001 | 0.54 (0.38–0.77) | < 0.001 | 0.70 (0.47–1.04) | 0.08 | NA | |
SARS-CoV-2 positivity of index HCW | NA | 10.6 (8.3–13.7) | < 0.001 | NA | ||||
Month of SARS-CoV-2 vaccination | 1.13 (1.07–1.19) | NA | NA | 1.14 (1.08–1.21) | < 0.001 | |||
Household related factors | ||||||||
Household size (per additional person) | 1.43 (1.30–4.57) | < 0.001 | 1.53 (1.35–1.73) | < 0.001 | 1.61 (1.40–1.85) | < 0.001 | 1.55 (1.32–1.81) | < 0.001 |
Always wearing a mask outside work | 1.25 (0.93–1.68) | 0.15 | 1.22 (0.83–1.78) | 0.32 | 0.99 (0.65–1.52) | 0.97 | 1.15 (0.72–1.82) | 0.56 |
At least one household contact with SARS-CoV-2 vaccination | 0.79 (0.61–1.01) | 0.06 | 1.12 (0.80–1.59) | 0.51 | 1.15 (0.78–1.68) | 0.48 | 1.47 (0.84–2.58) | 0.17 |
Children in household | 1.37 (1.12–1.68) | 0.003 | 0.70 (0.53–0.94) | 0.02 | 0.75 (0.55–1.04) | 0.09 | 0.65 (0.46–0.93) | 0.02 |
Pet in household | 1.06 (0.86–1.30) | 0.61 | 0.96 (0.78–1.19) | 0.73 | 1.03 (0.81–1.31) | 0.80 | 1.06 (0.81–1.38) | 0.68 |