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Table 1 Clinical records of patients in the outbreak

From: Emergence and clonal expansion of Aeromonas hydrophila ST1172 that simultaneously produces MOX-13 and OXA-724

Characteristic

Patient 1

Patient 2

Patient 3

Patient 4

Sex

Male

Male

Female

Male

Age (years)

36

73

77

38

Admission date

July 29, 2019

July 19, 2019*

July 29, 2019

August 29, 2019

Diseases related to admission for spine surgery

Cervical spondylosis

Lumbar spinal stenosis, lumbar disc herniation

Lumbar spinal stenosis, lumbar disc herniation

Kyphosis

Underlying diseases

None

Hypertension, hepatitis B infection

Diabetes

Ankylosing spondylitis

Surgery date

August 2, 2019

July 26, 2019*

August 5, 2019

September 3, 2019

Location of surgery

Cervical

Lumbar

Lumbar

Thoracolumbar

Implants

Yes

Yes

Yes

Yes

Date of fever

onset

August 6, 2019

August 7, 2019*

August 15, 2019

None

Days of onset of

fever following

surgery

Four

12

10

None

First isolation of A. hydrophila

August 6, 2019

August 11, 2019

August 13, 2019

September 9, 2019

Symptoms

Fever

Fever, chills

Fever, redness, and swelling of the right upper limb

None

Treatments

MRP, VAN

CAZ, MRP, VAN, ATM, LEV, CFM

FEP, MRP, VAN, LZD, LEV

MRP, VAN, LZD, CFM

Discharge date

September 4, 2019

August 26, 2019

September 20, 2019

September 16, 2019

Days of hospitalization

37

38

53

18

Complications

CSF leak, poor wound healing

CSF leak, atrial fibrillation, acute kidney injury

CSF leak, poor wound healing, acute heart failure

Implant fracture 1 year after surgery

  1. MRP, meropenem; VAN, vancomycin; CAZ, ceftazidime; CFM, cefixime; FEP, cefepime; ATM, aztreonam; LEV, levofloxacin; LZD, linezolid; CSF, cerebrospinal fluid
  2. * The patient 2 developed a fever on July 26, 2019, the day of the spine surgery. Although ceftazidime was administered, the fever persisted for four days, and A. hydrophila was not detected during that period. On August 7, 2019, due to a CSF leak, the patient received puncture of subcutaneous effusion near the surgical site. On the same day, the patient developed another fever, and A. hydrophila was identified in the blood cultures four days later