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Table 1 Main characteristics of patients and admissions

From: Efficacy of an antimicrobial stewardship intervention for early adaptation of antibiotic therapy in high-risk neutropenic patients

Patient characteristics

Pre-intervention period (n = 47)

Intervention period (n = 48)

p value

Age (years)

61 (44.5–66)

60.5 (54–67.25)

0.099

Sex (female), n (%)

26 (55)

18 (38)

0.082

Underlying hematologic disease, n (%)

  

0.065

 Acute myeloid leukemia

22 (47)

29 (61)

 

 Acute lymphoblastic leukemia

3 (6)

0 (0)

 

 Multiple myeloma

7 (15)

5 (10)

 

 Lymphoma

9 (20)

2 (4)

 

 Myelodysplastic syndrome

3 (6)

3 (6)

 

 Myelofibrosis

2 (4)

5 (10)

 

 Other

1 (2)

4 (9)

 

Charlson Comorbidity Index

4 (3–4)

4 (3–5)

0.126

Colonization with MDR bacteria, n (%)

5 (11)

3 (6)

0.486

Admission characteristics

Pre-intervention period (n = 56)

Intervention period (n = 57)

p value

Reason for admission, n (%)

  

0.095

 Induction

14 (25)

26 (46)

 

 Consolidation

8 (14)

4 (7)

 

 Conditioning for autologous HSCT

11 (20)

6 (10)

 

 Conditioning for allogeneic HSCT

22 (39)

21 (37)

 

 Microtransplantation

1 (2)

0 (0)

 

Duration of neutropenia (days)

14 (10–22)

18 (13–24)

0.121

  1. Data are presented as median (interquartile range) unless otherwise indicated
  2. Colonization with MDR bacteria was defined as colonization with methicillin-resistant Staphylococcus aureus or extended-spectrum beta-lactamase producing Enterobacterales
  3. Abbreviations: HSCT: Hematopoietic stem cell transplantation; MDR: Multidrug-resistant