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Table 2 Main characteristics of febrile neutropenia episodes

From: Efficacy of an antimicrobial stewardship intervention for early adaptation of antibiotic therapy in high-risk neutropenic patients

 

Pre-intervention period (n = 56)

Intervention period (n = 57)

p value

Total number of fever episodes, n

87

103

 

Number of fever episodes per admission

1 (1–2)

2 (1–2)

0.08

Number of fever episodes per admission, n (%)

   

 1

33 (59)

24 (42)

 

 2

15 (27)

20 (35)

 

 3

8 (14)

13 (23)

 

Type of fever episodes, n (%)

  

0.35

 MDI

19 (22)

32 (31)

 

  Bacteremia

9 (48)

18 (57)

 

  Urinary tract infection

4 (21)

3 (9)

 

  CVC-related infection

4 (21)

8 (25)

 

  Clostridioides difficile infection

1 (5)

0 (0)

 

  Fungal infection

1 (5)

3 (9)

 

 CDI

36 (41)

39 (38)

 

  Oral mucositis/dental

9 (25)

6 (15)

 

  Abdominal

9 (25)

8 (21)

 

  Skin and soft tissue

0 (0)

6 (15)

 

  Pulmonary

7 (20)

8 (21)

 

  Perianal

4 (11)

3 (8)

 

  CVC

3 (8)

3 (8)

 

  Multiple

4 (11)

5 (12)

 

 FUO

32 (37)

32 (31)

 

Duration of fever episode (days)

4 (2–7)

3 (2–5)

0.326

Fever recurrence, n (%)

31 (36)

46 (45)

0.207

Time to fever recurrence (days)

6 (4–10.5)

7 (4–10)

0.896

Sepsis, n (%)

7 (8)

9 (9)

0.864

Septic shock, n (%)

2 (2)

3 (3)

1

  1. Data are presented as median (interquartile range) unless otherwise indicated
  2. Abbreviations: CDI: Clinically documented infection; CVC: Central venous catheter; FUO: Fever of unknown origin; MDI: Microbiologically documented infection