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Table 3 Applicability and compliance with early de-escalation and discontinuation strategies

From: Efficacy of an antimicrobial stewardship intervention for early adaptation of antibiotic therapy in high-risk neutropenic patients

 

Pre-intervention period (n = 87)

Intervention period (n = 103)

Episodes when strategies applicable, n (%)

49 (56)

71 (69)

 Compliance*, n (%)

4 (8)

55 (77)

  De-escalation

4 (8)

12 (17)

  De-escalation followed by discontinuation

0 (0)

6 (8)

  Discontinuation

0 (0)

37 (52)

 Non-compliance*, n (%)

45 (92)

16 (23)

  Lack of timelinessa

2 (4)

11 (16)

  Continuation

40 (82)

3 (4)

  Escalation

3 (6)

2 (3)

Episodes when strategies not applicable, n (%)

38 (44)

32 (31)

  1. *p < 0.001 for the comparison of compliance between pre-intervention and intervention periods
  2. aLack of timeliness was defined as a delay of more than 48 h in the application of early discontinuation or de-escalation strategies