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Table 3 Rates of substrate (β-lactam) hydrolysis and inhibitor profiles of Acinetobacter spp. isolated from the ICU of Afzalipoor Hospital.

From: Antibiotic resistance patterns and extended-spectrum β-lactamase production among Acinetobacter spp. isolated from an intensive care Unit of a hospital in Kerman, Iran

Substrate MIC (µg/mL) β-lactamase
inhibitor
Substrate
hydrolysis (µmol)
CTX >240 - 80± 0.04
CTX >240 P-CMB (50mM) 80.2± 0.02
CTX >240 NaCl (100mM) 2.1± 0.01
CTX >240 Sulbactam (200µg/ml) 10.2± 0.03
CTX >240 Clavulanic (200µg/ml) 7.5± 0.02
CAZ >240 - 80± 0.04
CAZ >240 P-CMB (50mM) 80.2± 0.02
CAZ >240 NaCl (100mM) 2.1± 0.01
CAZ >240 Sulbactam (200µg/ml) 30.2± 0.03
CAZ >240 Clavulanic (200µg/ml) 7.5± 0.02
  1. β-lactamase inhibitors were added 15 min before addition of the substrate.
  2. P ≤ 0.05 was considered significant of association. The above results represent the mean of two independent experiments. Means and standard deviations (SD) were calculated as required for numerical variables.
  3. CTX = cefotaxime, CAZ = ceftazidime.