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Table 1 Clinical characteristics of patients with DNSE colonization or infection

From: Daptomycin exposure precedes infection and/or colonization with daptomycin non-susceptible enterococcus

Year, Age, Sex

Past Medical History

Total Days of Daptomycin Exposure

Species

Source

Reason for Admission and/or Complications

2011

     

55F

MDS, SCT

5

E. faecium

Blood, urine

Neutropenia, GVHD of gut

55F

ALL, BMT, DM, PVD

No

E. faecium

Blood

Neutropenia, CDI

58F

Gynecological malignancy

9

E. faecium

Blood

GI inflammation due to metastatic disease

59F

AML

19

E. faecium

Blood

Neutropenia, appendicitis

51F

AML, SCT

29

E. faecium

Urinea

Neutropenia, colitis

2010

     

74F

MDS, SBO, CHF, Pulmonary Htn

10

E. faecium

Urinea

Small bowel resection, sepsis

80F

CAD, COPD, PVD

No

E. faecalis

Urinea

Bowel ischemia after surgery

42 M

DM, bipolar disorder

12

E. faecium

Wound, lumbar

Chronic lumbar abscess

56F

AML, SCT, DM

67

E. faecium

Blood

Neutropenia, sigmoid colon perforation

2009

     

50F

AML, SCT

20

E. faecium

Urinea

Neutropenia, GVHD of gut, colitis

50 M

DM, Hip SSTI/osteomyelitis

19

E. faecium

Wound, hip

Hip SSTI / osteomyelitis

49 M

CAD, CHF, COPD, ESRD/HD, PVD

52

Not able to identify

Peritoneal fluid

GI perforation, peritonitis

37 M

Kidney-pancreas transplant, DM

11

E. faecium

Blood

Recurrent cholangitis

49 M

Kidney-pancreas transplant, DM

12

E. faecium

Blood

Intraabdominal abscess after surgery

2008

     

39 M

Hydrocephalus, VPS

25

E. faecium

Peritoneal fluid

GI perforation following MVA

61F

DM, endometrial malignancy

No

E. faecium

Urine

Pelvic exenteration, kidney abscess

78 M

CAD, CKD, CVA, DM

No

E. faecium

Urinea

Septic arthritis due viridans streptococci

57 M

Urinary bladder malignancy

No

E. faecium

Peritoneal fluid

Pelvic abscess after surgery

2007

     

59 M

MDS, BMT

8

E. faecium

Blood

Neutropenic fever, GVHD of gut

59F

DM, ESRD/HD, VHD

16

E. faecium

Urinea

Cryptococcal meningitis

2006

     

6F

Recurrent UTI

No

Not Available

Urine

UTI

46F

Cholangitis, DM, ESRD/HD

No

E. faecalis

Blood

Recurrent polymicrobial cholangitis

62 M

CAD, COPD

No

Not available

Urinea

Lumbar pain and sciatica

2005

     

38 M

DM, metastatic malignancy of colon

No

Not available

Urine

Chemotherapy, neutropenia, pyelonephritis

35F

DM, gastroparesis

No

Not available

Urinea

Recurrent gastroparesis

  1. Patient characteristics, past medical history, daptomycin exposure history (total days in prior year), isolate species, isolate source, and abbreviated reason for admission and/or complications arising during index admission for the 25 patients identified to be colonized or infected with DNSE during the study period.
  2. NOTE:
  3. a – Represents DNSE colonization.
  4. Abbreviations: ALL = acute lymphoblastic leukemia; AML = acute myelogenous leukemia; BMT = bone marrow transplant; CAD = coronary artery disease; CDI = Clostridium difficile infection; CHF = congestive heart failure; CKD = chronic kidney disease; COPD = chronic obstructive pulmonary disease; CVA = cerebro-vascular accident; DM = diabetes mellitus; ESRD/HD = end stage renal disease requiring hemodialysis; GI = gastrointestinal; GVHD = graft versus host disease; MDS = myelodysplastic syndrome; MVA = motor vehicle accident; PVD = peripheral vascular disease; SBO = small bowl obstruction; SCT = stem cell transplant; SSTI = skin and soft tissue infection; UTI = urinary tract infection; VHD = valvular heart disease; VPS = ventriculoperitoneal shunt; Pulmonary Htn = pulmonary hypertension.
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Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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