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Table 1 Clinical characteristics of patients with DNSE colonization or infection

From: Daptomycin exposure precedes infection and/or colonization with daptomycin non-susceptible enterococcus

Year, Age, Sex Past Medical History Total Days of Daptomycin Exposure Species Source Reason for Admission and/or Complications
55F MDS, SCT 5 E. faecium Blood, urine Neutropenia, GVHD of gut
55F ALL, BMT, DM, PVD No E. faecium Blood Neutropenia, CDI
58F Gynecological malignancy 9 E. faecium Blood GI inflammation due to metastatic disease
59F AML 19 E. faecium Blood Neutropenia, appendicitis
51F AML, SCT 29 E. faecium Urinea Neutropenia, colitis
74F MDS, SBO, CHF, Pulmonary Htn 10 E. faecium Urinea Small bowel resection, sepsis
80F CAD, COPD, PVD No E. faecalis Urinea Bowel ischemia after surgery
42 M DM, bipolar disorder 12 E. faecium Wound, lumbar Chronic lumbar abscess
56F AML, SCT, DM 67 E. faecium Blood Neutropenia, sigmoid colon perforation
50F AML, SCT 20 E. faecium Urinea Neutropenia, GVHD of gut, colitis
50 M DM, Hip SSTI/osteomyelitis 19 E. faecium Wound, hip Hip SSTI / osteomyelitis
49 M CAD, CHF, COPD, ESRD/HD, PVD 52 Not able to identify Peritoneal fluid GI perforation, peritonitis
37 M Kidney-pancreas transplant, DM 11 E. faecium Blood Recurrent cholangitis
49 M Kidney-pancreas transplant, DM 12 E. faecium Blood Intraabdominal abscess after surgery
39 M Hydrocephalus, VPS 25 E. faecium Peritoneal fluid GI perforation following MVA
61F DM, endometrial malignancy No E. faecium Urine Pelvic exenteration, kidney abscess
78 M CAD, CKD, CVA, DM No E. faecium Urinea Septic arthritis due viridans streptococci
57 M Urinary bladder malignancy No E. faecium Peritoneal fluid Pelvic abscess after surgery
59 M MDS, BMT 8 E. faecium Blood Neutropenic fever, GVHD of gut
59F DM, ESRD/HD, VHD 16 E. faecium Urinea Cryptococcal meningitis
6F Recurrent UTI No Not Available Urine UTI
46F Cholangitis, DM, ESRD/HD No E. faecalis Blood Recurrent polymicrobial cholangitis
62 M CAD, COPD No Not available Urinea Lumbar pain and sciatica
38 M DM, metastatic malignancy of colon No Not available Urine Chemotherapy, neutropenia, pyelonephritis
35F DM, gastroparesis No Not available Urinea Recurrent gastroparesis
  1. Patient characteristics, past medical history, daptomycin exposure history (total days in prior year), isolate species, isolate source, and abbreviated reason for admission and/or complications arising during index admission for the 25 patients identified to be colonized or infected with DNSE during the study period.
  2. NOTE:
  3. a – Represents DNSE colonization.
  4. Abbreviations: ALL = acute lymphoblastic leukemia; AML = acute myelogenous leukemia; BMT = bone marrow transplant; CAD = coronary artery disease; CDI = Clostridium difficile infection; CHF = congestive heart failure; CKD = chronic kidney disease; COPD = chronic obstructive pulmonary disease; CVA = cerebro-vascular accident; DM = diabetes mellitus; ESRD/HD = end stage renal disease requiring hemodialysis; GI = gastrointestinal; GVHD = graft versus host disease; MDS = myelodysplastic syndrome; MVA = motor vehicle accident; PVD = peripheral vascular disease; SBO = small bowl obstruction; SCT = stem cell transplant; SSTI = skin and soft tissue infection; UTI = urinary tract infection; VHD = valvular heart disease; VPS = ventriculoperitoneal shunt; Pulmonary Htn = pulmonary hypertension.