Table 1 Efficacy of three alcohol-based hand disinfectants; two experiments per product were performed according to EN 1500 (1997) to demonstrate a lack of superiority of the reference procedure using the Wilcoxon matched-pairs signed ranks test, one according to prEN 1500 (2009) to demonstrate non-inferiority of the test product using the Hodges & Lehmann (H&L) test
Test product | Active ingredient(s) (concentration; all w/w) | Mean log10-reduction reference procedure (2 × 3 ml for 2 × 30 s) | Mean log10-reduction product (3 ml for 30 s) | p-value/Hodges & Lehmann value |
|---|---|---|---|---|
Product 1 | Ethanol (70%) | 4.62 ± 0.89 | 3.87 ± 0.79 | p < 0.1 |
5.00 ± 0.87 | 4.38 ± 0.87 | p < 0.1 | ||
4.99 ± 0.90 | 4.06 ± 0.86 | H&L: 1.300 | ||
Product 2 | Ethanol (70%) | 4.65 ± 0.97 | 3.95 ± 0.75 | p < 0.1 |
5.00 ± 0.87 | 4.29 ± 0.76 | p < 0.1 | ||
4.93 ± 0.46 | 4.04 ± 0.92 | H&L: 1.365 | ||
Product 3 | Ethanol (60%), Isopropanol (15%) | 4.65 ± 0.97 | 3.99 ± 1.04 | p < 0.1 |
5.15 ± 0.75 | 5.30 ± 0.94 | n.a. | ||
4.99 ± 0.90 | 4.27 ± 0.72 | H&L: 1.095 |