Three models were used. First, to explore the relationship between antibiotic exposure and excretion of RB, piglets just received 15 or 1.5 mg/Kg/d of oral ciprofloxacin or placebo X 5 days. We then compared between groups fecal ciprofloxacin concentrations and the amount of RB excreted. Second, to explore colonic adsorption of antibiotics by DAV132 in the colon, dogs received 10.7 mg/kg/d of IV levofloxacin X 5 days together with 0.3 or 0.6 g/kg/d or placebo of oral DAV132. We then compared between groups fecal and blood levofloxacin concentrations. Last, to explore if DAV132 could restore antibiotic-associated disruption of colonization resistance (CR), mice received 300 mg/kg/d of sc cefotaxime or placebo X 3 days, together with 50 mg/d or placebo of oral DAV131 (DAV132 adapted to the mice), followed by gastric challenge with 106 CFU of a K. pneumoniae resistant to third generation cephalosporin (C3GR-Kp). We then compared between groups fecal cefotaxime and C3GR-Kp concentrations.